Historical Awareness 1690-Nicotine -water extracted from tobacco leaves sprayed on plants as insecticide > 1700's-Strychnine-extracted from plant used to kill rodents 1800's-Arsenic trioxide-weed killer >1800's-Rotenone-extracted from plants as insecticide > 1800's-Pyrethrum-extracted from chrysanthemum as insecticide >1900's-lead arsenate-orchard insecticide A Small Dose of Toxicology A Small Dose of Pesticide-2/29/04
A Small Dose of Toxicology A Small Dose of Pesticide – 2/29/04 ➢ 1690 – Nicotine - water extracted from tobacco leaves sprayed on plants as insecticide ➢ 1700’s – Strychnine – extracted from plant used to kill rodents ➢ 1800’s – Arsenic trioxide – weed killer ➢ 1800’s – Rotenone – extracted from plants as insecticide ➢ 1800’s – Pyrethrum – extracted from chrysanthemum as insecticide ➢ 1900’s – lead arsenate – orchard insecticide Historical Awareness
Historical Events >1930's-“ginger jake paralysis”- during prohibition,alcoholic Jamaican ginger >1962-“Silent Spring”by Rachel Carson exposed the hazards of DDT 1975-Works made ill from Kepone manufacture in Hopewell,Virginia A Small Dose of Toxicology A Small Dose of Pesticide-2/29/04
A Small Dose of Toxicology A Small Dose of Pesticide – 2/29/04 ➢ 1930’s – “ginger jake paralysis” – during prohibition, alcoholic Jamaican ginger ➢ 1962 – “Silent Spring” by Rachel Carson exposed the hazards of DDT ➢ 1975 – Works made ill from Kepone manufacture in Hopewell, Virginia Historical Events
Chlordane "Chlordane America's leading lawn and garden insecticide.Used extensively by pest control operators for termite control, because of its long lasting effectiveness." Velsicol Chemical Corporation- Advertisement-1959 U.S.EPA lists chlordane as a persistent bioaccumulative toxic.In 1978,EPA cancelled use of chlordane on food crops and 1988 all use was banned. A Small Dose of Toxicology A Small Dose of Pesticide -2/29/04
A Small Dose of Toxicology A Small Dose of Pesticide – 2/29/04 Chlordane “Chlordane America’s leading lawn and garden insecticide. Used extensively by pest control operators for termite control, because of its long lasting effectiveness.” Velsicol Chemical Corporation – Advertisement – 1959 U.S. EPA lists chlordane as a persistent bioaccumulative toxic. In 1978, EPA cancelled use of chlordane on food crops and 1988 all use was banned
What Is This? H ci ci CCl; A Small Dose of Toxicology A Small Dose of Pesticide -2/29/04
A Small Dose of Toxicology A Small Dose of Pesticide – 2/29/04 What Is This? Cl C H CCl3
DDT H ci CCl3 Organochlorine insecticide 1945 control of mosquitoes Effective but very persistent Very soluble in fat Damaged bird eggs A Small Dose of Toxicology A Small Dose of Pesticide-2/29/04
A Small Dose of Toxicology A Small Dose of Pesticide – 2/29/04 DDT Cl C H CCl3 • Organochlorine insecticide • 1945 control of mosquitoes • Effective but very persistent • Very soluble in fat • Damaged bird eggs