Water permeability of aquaporin-1(AQP1)expressed in Xenopus oocytes. When transferred to hypo-osmolar buffer for 2 min, control water-injected oocytes exhibit negligible swelling (left). Under the same conditions, oocytes previously injected with AQPl cRNA rapidly swell and explode(right
Water permeability of aquaporin-1 (AQP1) expressed in Xenopus oocytes. When transferred to hypo-osmolar buffer for 2 min, control water-injected oocytes exhibit negligible swelling (left). Under the same conditions, oocytes previously injected with AQP1 cRNA rapidly swell and explode (right)
The physiological importance of the aquaporins is perhaps most conspicuous in the kidney, where some 150-200 liters of water need to be resorbed from the primary urine each day. This is made possible mainly by the aQp1 and AQp2 aquaporins. vasa recta, while AQP2 is expressed in the collecting duct. a AQP1 is expressed in the proximal tubules and the descend expression of AQp2 at the plasma membrane is regulated by vasopressin, and decreased or increased aQp2 levels have been associated with nephrogenic diabetes insipidus as well as with several conditions associated with fluid retention such as congestive heart failure( King and Yasui, 2002)
The physiological importance of the aquaporins is perhaps most conspicuous in the kidney, where some 150-200 liters of water need to be resorbed from the primary urine each day. This is made possible mainly by the AQP1 and AQP2 aquaporins. AQP1 is expressed in the proximal tubules and the descending vasa recta, while AQP2 is expressed in the collecting duct. The expression of AQP2 at the plasma membrane is regulated by vasopressin, and decreased or increased AQP2 levels have been associated with nephrogenic diabetes insipidus as well as with several conditions associated with fluid retention such as congestive heart failure (King and Yasui, 2002)