(a) Unactivated Profilin TB 7,三 ATP-G-actin Actin PIP Polymerization (b) Activated ATB PA Figure 18-15, p 765 from: Molecular Cell Biology by Lodish et al. 2000, Freeman and Co. New York, NY
Actin Polymerization Figure 18-15, p 765 from: Molecular Cell Biology by Lodish et al. 2000, Freeman and Co. New York, NY
Ac (c) Assembly ATP ADP →(, Proline-rich P protein ADP (d)Exchange ATP-G-acti in ADP-G-actin ATP Figure 18-15, p 765 from: Molecular Cell Biology by Lodish et al. 2000, Freeman and Co. New York, NY
Actin Polymerization Figure 18-15, p 765 from: Molecular Cell Biology by Lodish et al. 2000, Freeman and Co. New York, NY
微丝的动态性质 ◆极性 ◆踏车现象( treadmilling) ◆微丝的动态平衡
微丝的动态性质 ◆极性 ◆踏车现象(treadmilling) ◆微丝的动态平衡
Actin filaments have polarity The actin monomers all orient with their actin-ADP cleft toward the same end of the filament, designated the minus end This 2D diagram is oversimplified Actin monomers spiral around the axis of the filament actin-ATP actin filament myosin heads The polarity of actin filaments may be visualized by decoration with globular heads(S1) cleaved off of myosin by proteases Bound myosin heads cause an appearance of arrowheads in electron micrographs
The polarity of actin filaments may be visualized by decoration with globular heads (S1) cleaved off of myosin by proteases. Bound myosin heads cause an appearance of arrowheads in electron micrographs. actin filament myosin heads − + Actin filaments have polarity. The actin monomers all orient with their cleft toward the same end of the filament, designated the minus end. This 2D diagram is oversimplified. Actin monomers spiral around the axis of the filament. − + actin-ADP actin-ATP
极性 (-)端 (+)端 加帽蛋白 (-)端(+)端 6 加帽蛋白
极 性