4明出 "o Research in toxicology must shift its emphasis to mechanistic research, or basic understanding of how a specific chemical or chemical class exerts its toxicological effect on living organisms at the molecular /eve/ ss It is only with the accumulation of substantial data and information of this nature that the existing principles and concepts of structure-activity relationship(SAR) can be developed further
4. Mechanistic toxicological research ❖ Research in toxicology must shift its emphasis to mechanistic research, or basic understanding of how a specific chemical or chemical class exerts its toxicological effect on living organisms at the molecular level. ❖ It is only with the accumulation of substantial data and information of this nature that the existing principles and concepts of structure-activity relationship (SAR) can be developed further
4明出 ss The sar of a chemical may involve one or more functional groups, the parents compounds or a combination of functional groups and the parent chemical or chemical class .s The elucidation of toxicological mechanisms on a chemical specific or class specific basis and the systematic compilation of this data will provide thea necessary foundation and guidance for the EnY molecular manipulation by synthetic chemists to develop safer chemicals
❖ The SAR of a chemical may involve one or more functional groups, the parents compounds or a combination of functional groups and the parent chemical or chemical class. ❖ The elucidation of toxicological mechanisms on a chemical specific or class specific basis and the systematic compilation of this data will provide the necessary foundation and guidance for the molecular manipulation by synthetic chemists to develop safer chemicals. 4. Mechanistic toxicological research
4明出 so To stimulate interest and provide academia with the means to undertake more basic research in toxicology, the appropriate institutions must accept the concept and actively participate by making funds available in this specific area of research o Without financial support for conduct of more basic mechanistic research, the opportunities for new, creative molecular structures that are both efficatious and safe will be severely limited
❖ To stimulate interest and provide academia with the means to undertake more basic research in toxicology, the appropriate institutions must accept the concept and actively participate by making funds available in this specific area of research. ❖ Without financial support for conduct of more basic mechanistic research, the opportunities for new, creative molecular structures that are both efficatious and safe will be severely limited. 4. Mechanistic toxicological research
o' The revision of the existing concepts and practices of chemical education at both undergraduate and graduate level is needed .o Separated mode of education traditionally .o Although the function of designing safer chemicals can be accomplished through multi-disciplinary collaboration among chemists, toxicologists pharmacologists, bio-chemists and others, it is believed that individuals with a combined knowledge s of chemical structure, industrial application and biological activity at the molecular level will performS more efficiently and effectively
5. Revision of chemical education ❖ The revision of the existing concepts and practices of chemical education at both undergraduate and graduate level is needed. ❖ Separated mode of education traditionally ❖ Although the function of designing safer chemicals can be accomplished through multi-disciplinary collaboration among chemists, toxicologists, pharmacologists, bio-chemists and others, it is believed that individuals with a combined knowledge of chemical structure, industrial application and biological activity at the molecular level will perform more efficiently and effectively
To provide adequate training of synthetic chemists interested in designing safer chemicals and destined for careers in both academia and industry, it is believed that new curricula(课程) should be developed to provide firm groundings in biochemistry, pharmacology and toxicology (药理学) (毒物学)
❖ To provide adequate training of synthetic chemists interested in designing safer chemicals and destined for careers in both academia and industry, it is believed that new curricula (课程) should be developed to provide firm groundings in biochemistry, pharmacology and toxicology. (药理学) (毒物学) 5. Revision of chemical education