ANGIOTENSIN II Alterod Altered Altered Peripheral Renal Hesistance Function Structure MECHANISMS 0 MECHANISMS 0 MECHANISMS 0 1. Direct vasoconstriction Direct effect to increase Na 1. Non-homodynamically- reabsorption in proximal mediated effects: Il.Enhancement of tubule. A.Increased expression ot peripheral noradrenergic ll.Release of aldosterone proto-oncogenes neurotransmissic n: B, Increased production of from adrenal cortex A.Increased NE release growth factors Decreased NE reuptake C. Increased synthesis of excre1i】 c. Increased vascular in distal nephron) extracellular matrix responsiveness proteins Ill.Altered renal hemodynamics Ill.Increased sympathetic Direct renal vasoconstriction I. Hemodynamically- discharge(CNS) Enhanced noradrenergic mediated effects: neurotransmission in A.Increased afterload kidnoy (cardiac) C.Incre sed renal sympathetic B. from adrenal medulla Increased wall tension tone (CNS) (vascular) RESULT 0 RESULT 0 RESULT 0 Vascular and Cardiac Rapid Pressor Response Slow Pressor Response Hypertrophy and Remodelling 人民只生公版松
第一节肾素-血管紧张素系统 Angiotensinogen Kininogen Renin Kallikrein Increased prostaglandir Angiotensin I Bradykinin svnthesis Converting enzyme (kininase ll) Angiotensin Il Inactive metabolites (2 Vasoconstriction Aldosterone Vasodilation secretion Increased peripheral Increased sodium Decreased periphera vascular resistance and water retention vascular resistance Increased Decreased blood pressure blood pressure 人凤只坐B版松
第一节 肾素-血管紧张素系统