The structure of mitochondrial DNA >Anderson Cambridge sequence Encode 13 kinds protein, 12S IRNA Cyt b 22 kinds tRNA,2 kinds rRNA 16S IRNA No introns ND6 ND5 >Two strands,H strand NDI 16569bp (outside),L strand (inside) ND2 401 ND 4 RND COXI G ND3 0 CoxI C0XⅡ ATPase 816 □ATPa3e86 □Complex1 ☐tRNAs ☐Cytochrome b☐Complex4 ☐IRNAs
➢ Anderson & Cambridge sequence The structure of mitochondrial DNA ➢ Encode 13 kinds protein, 22 kinds tRNA,2 kinds rRNA ➢ No introns ➢ Two strands, H strand (outside), L strand (inside)
The genetics characteristics of mitochondrial DNA >Semi-independent Complex Subunits Nuclear mtDNA I 41 34 7 I 4 4 0 瓜 11 10 1 V 13 10 3 V 14 12 2 83 70 13
➢ Semi-independent Complex Subunits Nuclear mtDNA Ⅰ 41 34 7 Ⅱ 4 4 0 Ⅲ 11 10 1 Ⅳ 13 10 3 Ⅴ 14 12 2 83 70 13 The genetics characteristics of mitochondrial DNA
The genetics characteristics of mitochondrial DNA >Semi-independent Non-universality of the genetic code
➢ Non-universality of the genetic code The genetics characteristics of mitochondrial DNA ➢ Semi-independent
Variations in the Genetic Code Codon Universal code mtDNA UGG Trp Trp UGA Stop Trp AGG Arg Stop AGA Arg Stop AUG Met Met AUA lle Met
Variations in the Genetic Code Codon Universal code mtDNA UGG Trp Trp UGA Stop Trp AGG Arg Stop AGA Arg Stop AUG Met Met AUA Ile Met