Vitamin d-Deficient rickets Epidemiology: rare in industrialized countries Common in China 20% in the South of china 30-40% in the north of China
Vitamin D-Deficient Rickets Epidemiology: ➢ rare in industrialized countries ➢ Common in China 20% in the South of China 30-40% in the North of China
Vitamin D deficiency Osteoid tissue Less ca absorbed from the intestin failure to mineralize Serum ca concentration decrease Osteoid tissue Parathormone accumulation secreted Urine phosphorus Low Mobilized increased serum bone ca p phosphor Normal o' Slight decrease in serum calcium concentration Serum AKP Vitamin D-deficient increased Rickets Pathophysiology of Vitamin D-deficient Rickets
Vitamin D deficiency Osteoid tissue failure to mineralize Osteoid tissue accumulation Less Ca absorbed from the intestine Urine phosphorus increased Parathormone secreted Serum AKP increased Mobilized bone Ca,P Vitamin D-deficient Rickets Serum Ca concentration decrease Low serum phosphor us Pathophysiology of Vitamin D-deficient Rickets Normal or slight decrease in serum calcium concentration
Cliniacl manifestations General manifestations: irritability, temporary teeth eruption delayed, anterior fontanel closure delayed Muscles lack of tone Head: craniotabes, Ping-Pong ball, caput quadratum Chest: beading of the ribs, pigeon breast deformity, Harrison groove Limb: Thickening of the wrists and ankles Bow-legs, knock-knees
➢ General manifestations: irritability, temporary teeth eruption delayed，anterior fontanel closure delayed ➢ Muscles lack of tone ➢ Head: craniotabes, Ping-Pong ball,caput quadratum ➢ Chest: beading of the ribs, pigeon breast deformity, Harrison groove ➢ Limb: Thickening of the wrists and ankles Bow-legs, knock-knees Cliniacl manifestations