Therapeuticusesschizophrenia精神分裂症more effective in treating positive symptomssevere nauseaandvomitinguseful in the treatment of drug-induced nausea■hypothermicanesthesia低温麻醉andartificialhibernation人工冬眠chlorpromazine-promethazine-pethidine（氯丙嗪一异丙嗪一哌替啶）
Therapeutic uses ◼ schizophrenia 精神分裂症 more effective in treating positive symptoms ◼ severe nausea and vomiting useful in the treatment of drug-induced nausea ◼ hypothermic anesthesia 低温麻醉 and artificial hibernation 人工冬眠 chlorpromazine – promethazine – pethidine （氯丙嗪 – 异丙嗪 – 哌替啶）
AdverseeffectscommonadverseeffectsCNSdepression(drowsiness,indifference)M-R block (blurred vision, dry mouth)α-Rblock（orthostatichypotension体位性低血压）extrapyramidalreaction锥体外系反应Parkinson'ssyndromakathisia静坐不能acutedystonia急性肌张力障碍treated by antimuscarinic drugs(artane,安坦）
Adverse effects ◼ common adverse effects CNS depression (drowsiness, indifference) M-R block (blurred vision, dry mouth) α-R block (orthostatic hypotension 体位性低血压) ◼ extrapyramidal reaction 锥体外系反应 Parkinson's syndrom akathisia 静坐不能 acute dystonia 急性肌张力障碍 treated by antimuscarinic drugs (artane,安坦 )
tardivedyskinesia迟发性运动障碍treatedbyantidopaminedrugs(clozapine,氯氮平）Neuralantagonistseveresymdromedrug-induced mindabnormalityconvulsion惊厥andepilepsy癫痫allergicreactionacute hypogranulocytosis（粒细胞减少症)cardiovascularandendocrinesystemreactionacutepoisoning急性中毒
tardive dyskinesia 迟发性运动障碍 treated by antidopamine drugs (clozapine,氯氮平) ◼ Neural antagonist severe symdrome ◼ drug-induced mind abnormality ◼ convulsion惊厥 and epilepsy癫痫 ◼ allergic reaction acute hypogranulocytosis (粒细胞减少症) ◼ cardiovascular and endocrine system reaction ◼ acute poisoning 急性中毒
Thioxanthenes硫杂葱类chlorprothixene氯普噻吨（泰尔登）Butyrophenones丁酰苯类haloperidol氟哌啶醇Otherspenfluridol五氟利多clozapine氯氮平
◆ Thioxanthenes 硫杂蒽类 chlorprothixene 氯普噻吨（泰尔登） ◆ Butyrophenones 丁酰苯类 haloperidol 氟哌啶醇 ◆ Others penfluridol 五氟利多 clozapine 氯氮平
Clozapine氯氮平）BenzodiazepinesPharmacologicaleffectBlocking 5-HT, D2 receptorStrong efficacy, rapidlyNoextrapyramidalreactionBlocking H, M andareceptorhypogranulocytosis
Clozapine (氯氮平) Benzodiazepines Pharmacological effect ◆ Blocking 5-HT, D2 receptor ◆ Strong efficacy, rapidly ◆ No extrapyramidal reaction ◆ Blocking H1 , M andαreceptor ◆ hypogranulocytosis