Antipsychotic drugsClassification:Phenothiazin盼噻嗪类（氯丙嗪chloropromazine）Thioxanthenes 硫杂葱类（chlorprothixene氯普噻吨（泰尔登））Butyrophenones丁酰苯类(haloperidol氟哌啶醇）Others
Antipsychotic drugs Classification： ◆ Phenothiazin 吩噻嗪类 (氯丙嗪 chloropromazine ) ◆ Thioxanthenes 硫杂蒽类 (chlorprothixene 氯普噻吨 （泰尔登）) ◆ Butyrophenones 丁酰苯类 (haloperidol 氟哌啶醇) ◆ Others
Antipsychotic/NeurolepticsPhenothiazin吩噻嗪类chlorpromazine氯丙嗪CHCH,CH2N(CH3)2（wintermine冬眠灵）Pharmacologiceffectsblocking DA2 、α、M、5HT2、H, receptors
Antipsychotic/Neuroleptics Phenothiazin 吩噻嗪类 chlorpromazine 氯丙嗪 (wintermine 冬眠灵) Pharmacologic effects blocking DA2 、α 、 M 、 5HT2 、 H1 receptors
neurolepticeffect（神经安定作用）>BlockingMesolimbic system and mesocorticalD2-R> More effective for treating positive symptom> Substantia nigra- corpus striatum---extrapyramidaleffects锥体外系反应>Node-funnel ---endocrine system action
◼ neuroleptic effect (神经安定作用) ➢ Blocking Mesolimbic system and mesocortical D2 -R ➢ More effective for treating positive symptom ➢ Substantia nigra- corpus striatum - extrapyramidal effects 锥体外系反应 ➢ Node-funnel - endocrine system action
powerfulantiemeticaction镇吐作用blockingCTZ催吐化学感受区D2-R(small dosage)directly inhibiting vomiting center 呕吐中枢(large dosage)alteringtemperature-regulatingmechanismsdecrease temperature no matter normal or hightemperaturebody temperature varies with the environment
◼ powerful antiemetic action 镇吐作用 blocking CTZ 催吐化学感受区 D2 -R (small dosage) directly inhibiting vomiting center 呕吐中枢 (large dosage) ◼ altering temperature-regulating mechanisms decrease temperature no matter normal or high temperature body temperature varies with the environment
autonomicNS effectsblockinga-Rvasodilatation“epinephrine reversal"blockingM-Ratropine-like actionendocrinesystemactionincreasingprolactin催乳素 secretioninhibitinggonadotropichormone促性腺激素,growthhormone生长激素secretion
◼ autonomic NS effects ◼ blocking α-R vasodilatation “epinephrine reversal” ◼ blocking M-R atropine-like action ◼ endocrine system action increasing prolactin催乳素 secretion inhibiting gonadotropic hormone促性腺激素， growth hormone生长激素 secretion