996年59月,日本O157型大肠杆菌出血性肠 炎大规模流行,波及36个都道府,发病1万多 人,并造成12人死亡,引起了全世界的关注 目前,日本、加拿大及瑞士等国已将“o157 列为必须报告的传染病。 我国也发现散发病例,尚未有爆发EHEc的报 道 我国广东检疫局在进口的一批24吨美国冷冻鸡 脯产品中,检验出O-157型致命性大肠杆菌
• 1996年5-9月，日本O157型大肠杆菌出血性肠 炎大规模流行，波及36个都道府，发病1万多 人，并造成12人死亡，引起了全世界的关注 • 目前，日本、加拿大及瑞士等国已将“O157” 列为必须报告的传染病。 • 我国也发现散发病例，尚未有爆发EHEC的报 道。 • 我国广东检疫局在进口的一批24吨美国冷冻鸡 脯产品中，检验出O-157型致命性大肠杆菌
Legionella(军团菌) Sources: naturally in water; multiplies in heating systems(e.g. air conditioning, cooling towers, showers) Potential Health Effects - Legionnaire‘ s Disease(军团病) a type of pneumonia
Legionella (军团菌) Sources: -- naturally in water; multiplies in heating systems (e.g. air conditioning, cooling towers, showers) Potential Health Effects: -- Legionnaire‘s Disease (军团病), a type of pneumonia
Aerosol (common) Wounds(rare) 3. Disease 2. Spread(rare) 4. Exit--none Pathogenesis of legionnaires Disease
Pathogenesis of Legionnaire‘s Disease
Structure legionella cells thin. somewhat pleomorphic(多形的) Gram-negative bacilli (arrows) impression smear from the lung of a patient fatally infected with 10 um Legionella
Structure Legionella cells • thin, somewhat pleomorphic（多形的） Gram-negative bacilli (arrows) • impression smear from the lung of a patient fatally infected with Legionella
Outbreak case (1)1976 in USA, the first outbreak an outbreak of the pneumonia-like diesease in a hotel in Philadelphia infected 221 individuals and killing 34 (2)1985 in England, the second largest outbreak 101 people infected and 28 died at the Stafford hospital (3)1987, first found in Beijing infection rate: 9. 9 in people who oft stay in hotel
Outbreak case: (1) 1976 in USA，the first outbreak -- an outbreak of the pneumonia-like diesease in a hotel in Philadelphia -- infected 221 individuals and killing 34 (2) 1985 in England, the second largest outbreak -- 101 people infected and 28 died at the Stafford hospital . (3) 1987, first found in Beijing -- infection rate: 9.9 % in people who oft stay in hotel