: b3 表 85
Clinical features decreasing of chief ce EPithelium atrophy parietal cell Abdominal discomfort Nausea pepsinogen Vomiting Gastric acid
Clinical features Epithelium atrophy Abdominal discomfort Nausea Vomiting ⚫decreasing of chief cell and ⚫ parietal cell pepsinogen Gastric acid
o Hypochlorhydria and pernicious anemia: severe parietal cell loss o Risk of gastric carcinoma: 29/0-4%
⚫ Hypochlorhydria and pernicious anemia: severe parietal cell loss ⚫ Risk of gastric carcinoma:2%-4%
peptic ulcer o peptic ulcers are chronic and solitary lesions occuring in the gastrointestinal tract o At least 98% of peptic ulcers are either in the first portion of the duodenum or in the stomach. in a ratio of about 4: 1
peptic ulcer ⚫ peptic ulcers are chronic and solitary lesions occuring in the gastrointestinal tract ⚫ At least 98% of peptic ulcers are either in the first portion of the duodenum or in the stomach,in a ratio of about 4:1
etiology o Main factors(70%-90%) o HP(infecting)+ ph(gastric acid others factors: drugs: NSAID heavy smoking alcohol Zollinger-ellison syndrome
etiology ⚫ Main factors(70%-90%): ⚫ HP(infecting)+ pH(gastric acid ) ⚫ others factors:drugs:NSAID heavy smoking alcohol Zollinger-Ellison syndrome