2. Lymphomas- Lymphocyte differentiation EARLY PRECURSOR PRE-B BCELL PLASMACELL PATHWAY CD19 D c19 CD19 DR TdT.--TdT CD10 CD22 c20 heavy t hght cha的n lg heavy and lightchain 300bp 150bp 7 TCR yand chain TCR B and a cha arrangements Cytotoxic TaT+ CD34 CD7 T-CELL PATHWAY EARLYTHYMOCYTES THYMOCYTES MATURE T CELLS
2. Lymphomas- Lymphocyte differentiation Phenotypic and genotypic changes in differentiation of B cells and T cells
3 Lymphomas-WHO Classification Hodgkin lymphoma, HL Non-Hodgkin lymphoma, NHL ▲ B-cell neoplasms A T-cell and NK cell neoplasms
Hodgkin lymphoma, HL Non-Hodgkin lymphoma, NHL ▲ B-cell neoplasms ▲ T-cell and NK cell neoplasms 3 Lymphomas- WHO Classification
sTaGinG, hd Nhd ONE NODE or NODE GROUP I MORE than ONE, but on ONE side of diaph I BOTH sides of diaph, but still in nodes only N OUTSIDE of NODES, e.g., liver, marrow, etc A No systemic symptoms B fever and/or night sweats and/or 10% weight loss
STAGING, HD & NHD • I ONE NODE or NODE GROUP • II MORE than ONE, but on ONE side of diaph. • III BOTH sides of diaph., but still in nodes only • IV OUTSIDE of NODES, e.g., liver, marrow, etc. • A No systemic symptoms • B fever and/or night sweats and/or 10% weight loss