2.神经元-神经元间化学性突触传递NerveimpPresynapticCa2+7membraneSynapticPostsynapticuterminalmembraneSPresynapticcellSynapticvesiclescontaining neuro-PostsynaptictransmittercellmoleculesNeurotransmitterNatReceptorSynapticcleftPostsynapticlonchannellonchannel(open)membrane(closed)lon channelproteinSNatPart ofdegradedneurotransmitterCopyright Pearson Education,Inc.,publishing as Benjamin Cummings
2. 神经元-神经元间化学性突触传递
Eatracotsasr.tiuidA membraneionchannelPolypeyedesubunst.The properties:ion selectivity andgating.ImpulseAxonAxonterminalPhoepholipidCytoss(a)bilayerPostsynapticdendriteNeurotransmitterRecordV.moleculesNaNaNat1SynapticcleftEPSPVmCytosol65mV26o8ATransmitter-gated(b)Timefrompresynapticactionpotential (msec)(c)ionchannels
A membrane ion channel •The properties: ion selectivity and gating
EtacellntaAmembraneionchannelPutvpelitide.The properties:ion selectivity andtantgating.ImpulseAxonAxonterminal(a)PhospholipidCytosobilayePostsynapticdendriteRecordVmNeurotransmittermoleculesSynapticcleftIPSPCytosol65mV-28064Transmitter-gated(b)(c)ionchannelsTimefrompresynapticactionpotential (msec)
A membrane ion channel •The properties: ion selectivity and gating
G-protein-gatedionchannelReceptorReceptorNeurotransmitterNeurotransmitterEnzymeG-proteinG-proteinSecondmessengers(a)(b)Transmitter actions at G-protein-coupled receptors.The binding of neurotransmitter to the receptor leads to theactivation of G-proteins.Activated G-proteins activate effectorproteins, which may be (a) ion channels or (b) enzymes thatgenerate intracellular second messengers
Transmitter actions at G-protein-coupled receptors. The binding of neurotransmitter to the receptor leads to the activation of G-proteins. Activated G-proteins activate effector proteins, which may be (a) ion channels or (b) enzymes that generate intracellular second messengers
总结：电生理学研究的指标·神经纤维上传导的动作电位（allornon，不衰减性传导）：分析其频率、潜伏期、传导速度；·神经元胞体及树突产生的局部电位（幅度总和）：感受器，突触后膜EPSP、IPSP，运动终板；神经递质和受体。·电压和化学门控通道：理、化性质
• 神经纤维上传导的动作电位（all or non ，不衰减性传导）： 分析其频率、潜伏期、传导速度； • 神经元胞体及树突产生的局部电位（幅度总和）：感受器， 突触后膜EPSP、IPSP，运动终板； • 神经递质和受体。 • 电压和化学门控通道：理、化性质。 总结：电生理学研究的指标