(2) Adult Stem Cells 成体干细胞 Adult stem cells are stem cells that can be found in a number of tissues and, depending on where they are from, have different properties 成体干细胞在人体内可能的分布 角膜、视网 皮肤 成体千细胞 存在于机体的多种 组织
16 ◆Adult stem cells are stem cells that can be found in a number of tissues and, depending on where they are from, have different properties. 成体干细胞: 存在于机体的多种 组织. （2）Adult Stem Cells 成体干细胞
角质层 毛囊生长初期毛囊生长中期毛囊生长末期 颗粒层 皮下腺 棘层 基底层 隆突 表皮 ]基质 毛囊 B 皮乳头 HSC 学杯细胞 一吸收细胞 肠内分泌细胞 隐窝干细胞 嗜酸细胞 小肠 大脑 造血系统E location of adult stem cells
17 location of adult stem cells
①造血干细胞 (hemopoietic stem cell, HSC) Hematopoietic stem cells(hscs) are multipotent stem cells that give rise to all the blood cell types including myeloid and lymphoid lineages T Lymphocyte 出生后定位于骨髓 Lymphoid Stem Cell thymus NK Lymphocyte 是多能的干细胞 Pluripotent B Lymphocyte Plasma Cell Stem Cell 是产生一切血细胞的 Megakaryocyte 原始细胞。 (blood clotting Stem Cell 标记物:CD34+ 来自骨髓的以 Monocyte Granulocytes
18 Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid and lymphoid lineages. ① 造血干细胞 （hemopoietic stem cell，HSC） 出生后定位于骨髓。 是产生一切血细胞的 原始细胞。 （来自骨髓的） 是多能的干细胞。 标记物：CD34+
②间充质干细胞 (mesenchymal stem cell, MSC) The Mesenchymal Stem cells are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, etc 主要存在于结缔组织、器 官间质,骨髓中最丰富。 Mesenchymal Stem Cell 为多能干细胞。 分化形成成骨细胞、软骨细胞, 肌细胞,脂肪细胞等 Osteoblasts Adipocytes Chondrocytes CD105(+)CD106(+)CD44(+) CD45(-)CD34(-)CD14( 19
19 ②间充质干细胞 (mesenchymal stem cell, MSC) The Mesenchymal Stem cells are multipotent stem cells that can differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes, adipocytes, etc. 主要存在于结缔组织、器 官间质，骨髓中最丰富。 为多能干细胞。 分化形成成骨细胞、软骨细胞， 肌细胞，脂肪细胞等。 CD105(＋)CD106(＋)CD44(＋) CD45(－)CD34(－)CD14(－)
2 In vitro differentiation of human mesenchymal stem cells(hMSC). The cultured hMSC could enter different cell lineages such as osteogenic(2) chondrogenic(3)and adipogenic(4)lineages. Undifferentiated control(1)
20 In vitro differentiation of human mesenchymal stem cells(hMSC). The cultured hMSC could enter different cell lineages such as osteogenic (2), chondrogenic (3) and adipogenic (4) lineages. Undifferentiated control (1)