Ancestry of The Hemoglobin Genes Ancestral Globin Gene Duplication Mutation t Transposition g Duplications and mutations 「②言 Fetus d Adt etus Adult Embryo Pseudogenes Embryo Pseudogenes oglobin gene family B-globin gene family chromosome 16 chromosome 11
Codons 13031104 105146 B-globin gene 850-900 5 3 Exon 1 Exon 2 Intron 2 Exon 3 1313299100141 Codons a-globin qene 3 Exon 1 Exon 2 Exon 3 02004006008001000120014001600bp
Developmental Expression of Globin Genes and Globin Switching (发育时珠蛋白基因的表达和 珠蛋自的转换)
Developmental Expression of Globin Genes and Globin Switching （发育时珠蛋白基因的表达和 珠蛋白的转换）
C201 a-like genes 5 3 Y FY β- like genes 3 Hb Gower 1 Hemoglobins Hb Gower 2 Hb F HbA HbA 2 Y 2B2 Hb Portland 22 Developmental Embryonic Fetal Adult pel Birth
Globin Gene Developmental Expression and Globin Switching Classic example of ordered regulation of developmental gene expression Genes in each cluster arranged in Same transcriptional orientation Same sequential order as developmental expression Equimolar production of a-like and B like globin chains
Globin Gene Developmental Expression and Globin Switching • Classic example of ordered regulation of developmental gene expression • Genes in each cluster arranged in – Same transcriptional orientation – Same sequential order as developmental expression • Equimolar production of α-like and β- like globin chains