进展一- brain Initiative( (Brain Research through Advancing Innovative Neurotechnologies) Three goals: To build new classes of tools that can simultaneously image or record the individual activity of most, or even all, neurons in a brain circuit, including those containing millions of neurons (i)To create tools to control the activity of every neuron individually in these circuits, because testing function requires intervention (ti)To understand circuit function within 5 years, it should be possible to monitor andor to control tens of thousands of neurons By year 10 that number will increase at least 10-fold By year 15, observing 1 million neurons with markedly reduced invasiveness should be possible
进 展 ——BRAIN Initiative (Brain Research through Advancing Innovative Neurotechnologies) Three goals: (i) To build new classes of tools that can simultaneously image or record the individual activity of most, or even all, neurons in a brain circuit, including those containing millions of neurons; (ii) To create tools to control the activity of every neuron individually in these circuits, because testing function requires intervention; (iii) To understand circuit function Within 5 years, it should be possible to monitor and/or to control tens of thousands of neurons. By year 10 that number will increaseat least 10-fold. By year 15, observing 1 million neurons with markedly reduced invasivenessshould be possible
Hodgkin and huxley 1952: The action potential is a consequence of permeability changes in the nerve membrane 50msec recorded from a giant neuron of a snail
Hodgkin and Huxley 1952: The action potential is a consequence of permeability changes in the nerve membrane ... recorded from a giant neuron of a snail
Ramon y cajal 1904 First, second and third layer of the cerebrum of a child of I month of age Our brain is a network of 10 neurons. each of which is connected with thousands of other cells by synapses D
Ramon y Cajal 1904 First, second and third layer of the cerebrum of a child of 1 month of age Our brain is a network of 1011 neurons, each of which is connected with thousands of other cells by synapses
Ramon y Cajal already predicted the direction of signal propagation and was mostly right a B C D
Ramon y Cajal already predicted the direction of signal propagation - and was mostly right -
脑活动功能一一感觉 b Skin Markel cells Cortex nechanoreceot Meissner's corpuscle neuron Proprioceptors Epidermis Nervous trent Dermis Second-order Spinal cord or brainstem Epidermis skeletal musch Afferent neuron Dermis (first-order neuron
脑活动功能——感觉