12SC50.5E8LILIF6*0.8-40.43xTg-AD112*0.3UUo.610F8S*0.2F60.440.1-15O0.2-20.00.0C-1LES-651XSbCheungKH,etal.2010
InsP3R channel gating is enhanced in FAD mouse cortical neurons Cheung KH, et al. 2010
i100nMl500-2 minCTL400-MW(u) [+zeol v300-200-100 nMl2 min100-A246EN/A010largeamplitudeCa2+transients5μg/mlCheungKH,etal.2010
Enhanced InsP3R channel gating results in increased Ca2+ release 5µg/ml large amplitude Ca2+ transients Cheung KH, et al. 2010
建100nMlEi.8050.8o*#*#60-0.6*###**400.4*200.25-00.010II191E10VEITI11665AspontaneouigvactivaieaJUUSCa2+oscillationsCheungKH,etal.2010
Enhanced InsP3R channel gating results in increased Ca2+ release Ca2+ oscillations 50 ng/ml IgM activated spontaneou s Cheung KH, et al. 2010
PlaquesAPPSAPPBSAPPaLiganda-secretaseExtracellularOPLCCytosol-secretaseB-secretaseInsP3FADPSRVHInsP3R000CytosolB-secretase-secretaseNormalPL0Extracellulara-secretaseASAPPBAPPSAPPaCheungKH,etal.2010
Hypothetical molecular mechanism of enhanced Aβ production due to Ca2+ disruption in FAD PS cells Cheung KH, et al. 2010
水amyloidchannelhypothesisMasahiro K. et al. 2000Interactionsof ABwithvariousCa-permeable channels including voltage-gated Ca2+ channels (N, P, and Q),nicotinic acetylcholine channels, glutamatereceptors (AMPA and NMDA), dopaminereceptors, serotonin receptors , andintracellularInsP3RsDemur0 A, et al. 2010
Ⅲ. How does Αβ disturb intracellular Ca2+ homeostasis？ • amyloid channel hypothesis Masahiro K, et al. 2000 • Interactions of Αβ with various Ca- permeable channels including voltage- gated Ca2+ channels (N, P, and Q), nicotinic acetylcholine channels, glutamate receptors (AMPA and NMDA), dopamine receptors, serotonin receptors , and intracellular InsP3Rs. Demuro A, et al. 2010