乙肝 (6)HBVDNA 是病毒复制和有传染性最直接的证据 检测方法：斑点杂交法、PCR法 (7)DNAP(DNA多聚酶)：是逆转录酶 也是直接反应病毒复制的指标之一 (8)HBxAg:也可作为病毒复制的标志 HBxAg具有反向激活作用，可调控病毒基因转录水 平，并对宿主癌基因可能有激活作用
（6）HBV DNA 是病毒复制和有传染性最直接的证据 检测方法：斑点杂交法、PCR法 （7）DNAP（DNA多聚酶）：是逆转录酶 也是直接反应病毒复制的指标之一 乙 肝 （8）HBxAg：也可作为病毒复制的标志 HBxAg具有反向激活作用，可调控病毒基因转录水 平，并对宿主癌基因可能有激活作用
Acute Hepatitis B Virus Infection with Recovery Typical Serologic Course Symptoms HBeAg anti-HBe Total anti-HBc Titre HBsAg IgM anti-HBc anti-HBs 04812162024283236 52 100 Weeks after Exposure
Symptoms HBeAg anti-HBe Total anti-HBc HBsAg IgM anti-HBc anti-HBs 0 4 8 12 16 20 24 28 32 36 52 100 Acute Hepatitis B Virus Infection with Recovery Typical Serologic Course Weeks after Exposure Titre
Progression to Chronic Hepatitis B Virus Infection Typical Serologic Course Acute Chronic (6 months) (Years) HBeAg anti-HBe HBsAg Total anti-HBc Titre IgM anti-HBc 04812162024283236 52 Years Weeks after Exposure
IgM anti-HBc Total anti-HBc HBsAg Acute (6 months) HBeAg Chronic (Years) anti-HBe 0 4 8 12 16 20 24 28 32 36 52 Years Weeks after Exposure Titre Progression to Chronic Hepatitis B Virus Infection Typical Serologic Course
Outcome of Hepatitis B Virus Infection 100- by Age at Infection 100 80 80 60 60 Chronic Infection 40 Chronic Infection (% 40 Symptomatic Infection (% 20 20 Symptomatic Infection 0 Birth 1-6 months 7-12 months 1-4 years Older Children and Adults Age at Infection
Symptomatic Infection Chronic Infection Age at Infection Chronic Infection (%) Symptomatic Infection (%) Birth 1-6 months 7-12 months 1-4 years Older Children and Adults 0 20 40 60 80 100 100 80 60 40 20 0 Outcome of Hepatitis B Virus Infection by Age at Infection Chronic Infection (%)
乙肝 ●介绍三个概念： ① “两对半” 2 血清e抗原血清转换：HBeAg消失，抗-HBe阳性 “转阴” 常用指标：血清HBeAg抗原一抗体转换率 HBV DNA阴转率
乙 肝 ●介绍三个概念： ① “两对半” ② 血清e抗原血清转换：HBeAg消失，抗-HBe阳性 ③ “转 阴” 常用指标：血清HBeAg抗原—抗体转换率 HBV DNA 阴转率