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CRCI 坐 Cancer Research Center Shandong University 23文献数据库 Pubmed 查看文章摘要等信息以及原文链接 CBI Resources回 How To國 Sign in to NCBI PubmEd.ov PubMed US Natonal Library of Medicine National Inst tutes of Health Advanced Abstract Full text links JMro1999Jan;73(1):751-3. FREE Hidden "dUTPase sequence in human immunodeficiency virus type 1 gp120 FINAL VERSION Abergel C1, Robertson DL, Claverie JM FREE PMC Full text Author information "Laboratory of Structural and Genetic Information, CNRS EP-91, Marseille F-13402, France chantal@igs.cnrs-mrsfr Abstract A coding region homologous to the sequence for essential eukaryotic enzyme dUTPase has been identified in different genomic regions of several viral lineages. Unlike the nonprimate lentiviruses(caprine arthritis encephalitis virus, equine infectious anemia virus, feline immunodeficiency virus, and visna virus), where duTPase is integrated into the pol coding region, this enzyme has never been demonstrated to be present in the primate lentivirus genomes(human immunodeficiency virus type 1 HIV-1], HIV-2, or the related similarity between HIV-1 gp120 and the human dUTPase. This finding was then extended to all of the simian immunodeficiency virus). A novel approach allowed us to identify a weak but significant sequene primate lentivirus lineages. Together with the recently reported fragmentary structural similarity between the V3 loop region and the Escherichia coli dUTPase(P. D Kwong, R. Wyatt, J. Robinson, R. W. Sweet,J Sodroski, and W.A. Hendrickson, Nature 393: 648-659, 1998), our results strongly suggest that an ancestral
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CRCI 坐 Cancer Research Center Shandong University 23文献数据库 Pubmed 从原文所在杂志下载全文阅读 Journal of Virology Search)(Jo JVI Article I Journal Info. I Authors I Reviewers I Permissions I Joumals ASM. org Journal List >J Virol >v. 73(1): Jan 1999 Formats: Abstract I Full Text PDF (1.8M) Jvro.199 January7301):751-753 PMCID: PMC103883 PubMed articles by these authors Copyright@ 1999, American Society for Microbiology Note Hidden"dUTPase Sequence in Human Immunodeficiency Hidden "dUTPase Sequence in Human Immunodeficiency b Robertson Claverie MMD!D口Nawa Virus Type 1 gp120 PubMed relat Chantal Abergel, David L. Robertson, and Jean-Michel Claverie Caprine artl e Laboratory of Structural and Genetic Information, CNRS EP-91, Marseille F-13402, France CNRS EP-91, 31 Chemin Joseph-Aiguier, Marseille F-13402, France. Phone: 33 91 16 45 48. inner-domal ss Corresponding author. Mailing address: Laboratory of Structural and Genetic Information Fax:33449.E-mail:chantal@igs.cnrs-mrsfr Distinct su Received July 27, 1998; Accepted October 14, 1998 This article has been cited by other articles in PMC virulence ABSTRACT Other Sections" hypothesis A coding region homologous to the sequence for essential eukaryotic enzyme 三器 duTPase has been identified in different genomic regions of several viral lineages Recent Act
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CRCI 坐 Cancer Research Center Shandong University 23文献数据库 Pubmed 改显示摘要为显示 MEDLINE NCBI Resources How To回 Sign in to NCBI PubmEd. gow US Natonal Library of Medicine Natonal Institutes of Health Advanced Abstract Send to Full text links SUmmary sequence in human immunodeficiency virus type 1 gp120 JⅥ FREE ANAL VERSION O Summary(text) ○ Abstract PMC Full text OMEDLINE ○XML and Genetic Information, CNRS EP-91, Marseille F-13402, France OPMID List ROSLavL A coding region homologous to the sequence for essential eukaryotic enzyme dUTPase has been identifier in different genomic regions of several viral lineages. Unlike the nonprimate lentiviruses(caprine arthritis encephalitis virus, equine infectious anemia virus, feline immunodeficiency virus, and visna virus), where duTPase is integrated into the pol coding region, this enzyme has never been demonstrated to be present in the primate lentivirus genomes(human immunodeficiency virus type 1 [HIV-1]. HIV-2, or the related simian immunodeficiency virus ). A novel approach allowed us to identify a weak but significant sequence similarity between Hiv-1 gp120 and the human duTPase. This finding was then extended to all of the primate lentivirus lineages. Together with the recently reported fragmentary structural similarity between the V3 loop region and the Escherichia coli dUTPase(P D Kwong, R. Wyatt, J. Robinson, R. W. Sweet, J Sodroski, and W.A. Hendrickson, Nature 393: 648-659, 1998), our results strongly suggest that an ancestral
2153 2.3 文献数据库PubMed 改显示摘要为显示MEDLINE