Law of Genetic Equilibrium Hardy-Weinberg law Hardy GH Weinberg W
Law of Genetic Equilibrium Hardy-Weinberg law Hardy GH Weinberg W
Law of Genetic Equilibrium Hardy-Weinberg law Explains how Mendelian segregation influences allelic and genotypic frequencies in a population
Explains how Mendelian segregation influences allelic and genotypic frequencies in a population. Law of Genetic Equilibrium Hardy-Weinberg law
Law of Genetic Equilibrium Hardy-Weinberg law Assumptions *Large population Random mating No natural selection *No mutation No migration If assumptions are met,population will be in genetic equilibrium
Law of Genetic Equilibrium Assumptions ❖ Large population ❖ Random mating ❖ No natural selection ❖ No mutation ❖ No migration If assumptions are met, population will be in genetic equilibrium. Hardy-Weinberg law
Law of Genetic Equilibrium Hardy-Weinberg law >Allele frequencies do not change over generations. Genotypic frequencies will remain in the following proportions: p+q=1 frequency of AA r+2p9+q=1 21pq： frequency of Aa frequency of aa
➢ Allele frequencies do not change over generations. p＋q＝1 p 2＋2pq＋q 2＝1 p 2 : frequency of AA 2pq: frequency of Aa q 2 : frequency of aa Law of Genetic Equilibrium Hardy-Weinberg law ➢ Genotypic frequencies will remain in the following proportions:
例：上海人群的MN血型分布（共1788人） M血型：397人（基因型虹MLM 调查结果 MN血型：861人（基因型LML) N血型：530人（基因型虹NLy 根据调查结果及基因频率与基因型频率的关 系计算基因频率 39711 p=i+2m788 861 =0.46 1788 g=【sN= 861 =0.54
例：上海人群的MN血型分布(共1788人) M血型：397人(基因型LMLM) MN血型：861人(基因型LMLN) N血型：530人(基因型LNLN) 1788 530 861 1788 + × 1 2 ＝0.54 1 2 q＝ fNN+ fMN ＝ ＝0.46 1788 397 861 1788 + × 1 2 1 2 p＝ fMM+ fMN ＝ 根据调查结果及基因频率与基因型频率的关 系计算基因频率： 调查结果