Genetically Engineered Microorganisms o Many high-value-added peptide drugs are produced by genetically engineered micro- organisms Blood proteins(Erythropoietin, Factors VIl, VIL, IX Human hormones(Epidermal growth factor, Human growth hormone, Insulin, Nerve growth factor Immune modulators(a-Interferon, B-Interferon) Vaccines(Hepatitis B, Measles, Rabies)
Genetically Engineered Microorganisms ⚫ Many high-value-added peptide drugs are produced by genetically engineered microorganisms: Blood proteins (Erythropoietin, Factors VII, VIII, IX) Human hormones (Epidermal growth factor, Human growth hormone, Insulin, Nerve growth factor) Immune modulators (a-Interferon, b-Interferon) Vaccines (Hepatitis B, Measles, Rabies)
Five Common characteristics of Microorganisms 1. Small volume, large surface area 2. Fast absorption and conversion 3. Rapid duplication and growth 4. Strong adaptability 5. Widespread distribution and diversified species
Five Common Characteristics of Microorganisms 1. Small volume, large surface area 2. Fast absorption and conversion 3. Rapid duplication and growth 4. Strong adaptability 5. Widespread distribution and diversified species
Five common characteristics of Microorganisms Typical animal cell Small volume large surface area Figure on the left The size of a virus in comparison to a bacterial and animal ce 1000 nm-1 um
Five Common Characteristics of Microorganisms 1. Small volume, large surface area. Figure on the left: The size of a virus in comparison to a bacterial and animal cell
Five common characteristics of Microorganisms 2. Fast absorption and conversion For example 5 gl of bacteria(cell dry weight Azotobacter vinelandii uwd can consumed 10 g/l of glucose to double its weight to 10 g within less than 5h How about you?-
Five Common Characteristics of Microorganisms 2. Fast absorption and conversion For example: 5 g/l of bacteria (cell dry weight) Azotobacter vinelandii UWD can consumed 10 g/l of glucose to double its weight to 10 g/l within less than 5 h. How about you?
Five common characteristics of Microorganisms 3. Rapid duplication and growth An echerische coli(大肠杆菌) cell can double itself within 15 minutes it also means its weight increases one fold within 15 minutes How fast can you grow?
Five Common Characteristics of Microorganisms 3. Rapid duplication and growth An Echerische coli (大肠杆菌）cell can double itself within 15 minutes, it also means its weight increases one fold within 15 minutes. How fast can you grow? ?