Structure of HIv particle ·Core +ssRNA copies P orease Docking Glycoprotein reverse transcriptase (RT, an rna dependent dna Lipid RNA gp41 Membrane polymerase Transmembrane Glycoprotein 1 capsid (P24) P24 gaopI Matrix protein · Envelope Integrase gp120 Nucleocapsid Reverse Transcriptase o vif, Vpr, Nef and p7 Diameter: N 100 nm www.wikidoc.org
• Core – +ssRNA 2copies – reverse transcriptase (RT, an RNA dependent DNA polymerase) – P24 • Envelope --gp120 --gp41 Diameter: ~ 100 nm (P24) Structure of HIV particle www.wikidoc.org
HIV genome LTR LTR tat. gag vif vpr vpu tat nef rev 1 RNA 10 kb),9 genes long terminal repeat,LTR(5’,3’-end) 长末段重复序列 ·3 structura| genes gag >P55>P24, P17, P6, P7 pol >RT, integrase rNase h and protease env> glycoprotein(gp120 and gp41 6 regulator genes tat, rev and nef are most important
HIV genome • 1 RNA (~ 10 kb), 9 genes • long terminal repeat, LTR (5’, 3’- end) • 3 structural genes – gag → P55 → P24, P17, P6, P7 – pol → RT, integrase, RNase H and protease – env → glycoprotein (gp120 and gp41) • 6 regulator genes tat, rev and nef are most important 长末段重复序列
Replication cycle of HIv GP120 reverse transcriptase capside Integrase protease RNA Attachment HIV CD4 Endocytosis CCR5 or CXCR4 co-receptor clathria Limited proteolysis Assembl and release Translation (protein synthesis) Removal of the protein envelopes mRNA o Revers transcriptation Integrationg Transcription ● cellular dna Watch video http://www.hhmi.org/biointeractive/hiv-life-cycle
Replication cycle of HIV http://www.hhmi.org/biointeractive/hiv-life-cycle Watch video: