Chapter 7 Endomembrane system, Protein Sorting and membrane trafficing Learning obiective 1. Compartmentalization in Eukaryotic Cells 2. The structural and functional relationship between the ER, Golgi complexes, lysosomes and plasma membranes of eukaryotic cells 3. The pathways of proteins targeting and sorting, and its mechanisms 4. The ways of protein modifications and intracellular sites after they are synthesized; 5. Types of vesicle transport and their functions
Chapter 7 Endomembrane system, Protein Sorting and membrane trafficing Learning objective 1. Compartmentalization in Eukaryotic Cells; 2. The structural and functional relationship between the ER, Golgi complexes, lysosomes and plasma membranes of eukaryotic cells; 3. The pathways of proteins targeting and sorting, and its mechanisms; 4. The ways of protein modifications and intracellular sites after they are synthesized; 5. Types of vesicle transport and their functions
1. The Compartmentalization in Eukaryotic Cells Membranes divide the cytoplasm of eukaryotic cells into distinct compartments Tree categories in eukaryotic cells: )the endomembrane system: ER, Golgi complex, Lys secretory vesicles (2)the cytosol (3)mitochondria, chloroplasts, peroxisomes, and the nucleus Membrane-bound structures (organelles)are found in all eukaryotic cells
1. The Compartmentalization in Eukaryotic Cells vMembranes divide the cytoplasm of eukaryotic cells into distinct compartments. Tree categories in eukaryotic cells: (1) the endomembrane system: ER, Golgi complex, Lys., secretory vesicles. (2) the cytosol. (3) mitochondria, chloroplasts, peroxisomes, and the nucleus. vMembrane-bound structures (organelles) are found in all eukaryotic cells
A Cytosol and its functions >Cytosol: The region of fluid content of the cytoplasm outside of the membranous organelles. Aqueous solution of large and small molecules including filaments of cytoskeleton which act as organizer for some order >The cytosol is the site of protein synthesis and degradation or modification. It also performs most of the cell,s intermediary metabolism
ØCytosol: The region of fluid content of the cytoplasm outside of the membranous organelles. Aqueous solution of large and small molecules including filaments of cytoskeleton which act as organizer for some order. ØThe Cytosol is the site of protein synthesis and degradation or modification. It also performs most of the cell’s intermediary metabolism. A. Cytosol and its functions
B Endomembrane system x Endomembrane System The structural and functional elationship organelles including Er, Golgi complex, ysosome, endosomes, secretory vesicles. Membrane-bound structures (organelles) are found in all eukaryotic cells Endocytic Perinuclear space envelope
B. Endomembrane System vEndomembrane System : The structural and functional relationship organelles including ER,Golgi complex, lysosome, endosomes, secretory vesicles. vMembrane-bound structures (organelles) are found in all eukaryotic cells
rough endoplasmic reticulum nucleus lysosomes 来A|rcaL 5 um peroxisome mitochondrion