FilariaeWuchereria bancrofti and Brugia malayi
Filariae . Wuchereria bancrofti and Brugia malayi
Morphological Differences of Microfilariae between WbancrotiandB.malayiSpeciesW.bancroftiB. malayiAppearancegraceful,sweepingcurvesirregular,stiff curvesSizelarger244-296x7μmsmaller177-230×6μmCephalic spaceshorter(1:1 or1:2)longer(2:1)(length:width)Nucleibodynucleiequal sized,clearlyunequal sized,coalescingdefined,countableuncountabletwoTerminalnucleino
Morphological Differences of Microfilariae between W. bancroti and B. malayi _ Species W. bancrofti B. malayi _ Appearance graceful, sweeping curves irregular, stiff curves _ Size larger 244-296× 7 µm smaller 177-230 × 6 µm _ Cephalic space shorter(1:1 or1:2) longer(2:1) (length:width) _ Nuclei body nuclei equal sized, clearly unequal sized, coalescing, defined, countable uncountable _ Terminal nuclei no two _
Life cycle (summary)1.Humanity is the only known definitive host for W.bancrofti while there is still another variety ofBmalayithat infects monkeys andfelines2.Infective stage: filariform larva(L3);3.Infectiveroute:byskin4.Site of inhabitation:lymphatic tissue5.Thefemaleproducelarvae--microfilariae6.show“nocturnalMicrofilariaeofbothspeciesperiodicity
Life cycle (summary) 1. Humanity is the only known definitive host for W. bancrofti while there is still another variety of B. malayi that infects monkeys and felines. 2. Infective stage: filariform larva(L3); 3. Infective route: by skin 4. Site of inhabitation: lymphatic tissue 5. The female produce larvae- microfilariae 6. Microfilariae of both species show “nocturnal periodicity
Clinical manifestation1.Acutestage:filarial fever; lymphangitis ; lymphadenitis;orchitis and inflammation of spermatic cord.2. Chronic stage: (obstructive filariasis)(1)Elephantiasis;(2) Chyluria only caused by W.bancrofti.(3) Hydrocele is only found in infection of W.bancrofti.First choice drug is diethylcarbamazine （ DECHetrazan)
Clinical manifestation 1. Acute stage: filarial fever ； lymphangitis ； lymphadenitis ； orchitis and inflammation of spermatic cord. 2. Chronic stage: (obstructive filariasis) (1) Elephantiasis； (2) Chyluria only caused by W. bancrofti. (3) Hydrocele is only found in infection of W. bancrofti. First choice drug is diethylcarbamazine ( DEC, Hetrazan )
The Scopeof Human Parasitology.Three major groups of human parasitesHelminth:multiple cells(Trematoda, Cestoda, Nematoda)Protozoa:one-cell organismArthropods:
The Scope of Human Parasitology •Three major groups of human parasites •Helminth: multiple cells ( Trematoda, Cestoda, Nematoda) •Protozoa: one-cell organism •Arthropods: