Rignin-Anyioiensin-Allusigrone Sysiem Very potent vasoconstrictor o Infusion of non- pressor doses of angiotensin Il increase blood pressure o Potent growth factor for smooth muscle cells Clinical studies with drugs interfering with the system are very effective in lowering blood pressure o Interacts with other vasoconstrictor systems
The Renin-Angiotensin System Pathway CE Angiotensin I (10aa) Angiotensinogen Angiotensin II (8a) Angiotensin Receptor VUU Renin Stimulus Low salt intake Low blood volume Sodium retention ShOw blood pressure Vasoconstriction
Dr. Sica 24 ACE Renin Angiotensinogen Angiotensin I (10 aa) Angiotensin II (8 aa) Stimulus Angiotensin Receptor Low salt intake Low blood volume Low blood pressure Sodium retention Vasoconstriction The Renin-Angiotensin System Pathway
Incidence of cv Complications As a function of Plasma renin Activity in Hypertension 25 20 15 I LVH Incidence Stroke 10 M 5 Low Normal High Plasma Renin Activity Brunner HR et al. N Eng/J Med. 1972: 286: 441-449
0 5 10 15 20 25 Low Normal High LVH Stroke M I Incidence (%) Plasma Renin Activity Brunner HR et al. N Engl J Med. 1972;286:441-449. Incidence of CV Complications As a Function of Plasma Renin Activity in Hypertension
Pathophysioloyisil Aspseis oi Prinmry Hlyperisnsion ◆ Salt and the kidney o Sympathetic nervous system O Renin-Angiotensin-Aldosterone System C Hemodynamics and structural changes ◆ Endothelial factors
Siruciuril Rginforeemgns: i Lony Loop oi fhg Syumpithsfit-Angiorensin bysryIs Interaction Angiotensin BP Vascular hypertrophy Other factore Sympathetic Trophies [ET-1, PDGF, ste effecte tone Js.2001