Epidemiology(2)IncidenceUSA:0.43%~0.69%o China : 0.11%o~0.35%文The reasons of these reported differences maybe include:-diagnostic criteria- areasmethods of casefinding,migration6
6 Epidemiology( 2) • Incidence – USA: 0.43‰~0.69‰ – China : 0.11‰~0.35‰ • The reasons of these reported differences may be include: – diagnostic criteria – areas – methods of case finding, migration
Epidemiology( 3)Age:the age of onset in 50% of patients is20~30 year old, over 80% of patients is16~35yearold.?Gender:Schizophrenia occurs equally in men andwomen(in abroad)- The prevalence in men is more than women(1.6:1) in China. The mean age of onset is about 2 to 5 yearsearlierinmenthan women
7 Epidemiology( 3) • Age：the age of onset in 50% of patients is 20~30 year old，over 80% of patients is 16~35year old. • Gender： – Schizophrenia occurs equally in men and women(in abroad) – The prevalence in men is more than women (1.6:1) in China. – The mean age of onset is about 2 to 5 years earlier in men than women
Outcome evaluation(multi-dimensionsClinicaloutcomeSocialfunction.Quality of life·Living condition·Family conditionothers8
8 Outcome evaluation(multi-dimensions) • Clinical outcome • Social function • Quality of life • Living condition • Family condition • others
History (1)1.Demence precoce(Morel,1857)2. Hebephrenia(Hecker,1871)3. Catatonia(Kzhlbaum,1874)4.Kraepelin(1896)thoughtall above descriptionsare differenttypes of the same disease-dementiapraecox9
9 History（1） 1. Demence precoce(Morel,1857) 2. Hebephrenia(Hecker,1871) 3. Catatonia(Kzhlbaum,1874) 4. Kraepelin(1896)thought all above descriptions are different types of the same disease-dementia praecox
History (2)E.Bleuler(1911)suggested that splitting of thoughtandaffectwas thecentralfeatureof theillness-schizophreniaHe found that the outcomeof this illness was neitheruniversallypoornorassociatedwithseveredementiaM.Bleuler-4A symptoms :Associationdisorder: ApathyAmbivalence- Autism10
10 History（2） E.Bleuler(1911)suggested that splitting of thought and affect was the central feature of the illness – schizophrenia He found that the outcome of this illness was neither universally poor nor associated with severe dementia. M.Bleuler- 4A symptoms： ▪ Association disorder ▪ Apathy ▪ Ambivalence ▪ Autism