Medical Genetics 2.Human genetic diversity Many mutations are not deleterious but are thought to be selectively neutral;some may even be beneficial. What makes us different from each other? ------Polymorphism. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics Genetic polymorphism The occurrence together in a population of two or more alternative genotypes,each at a frequency greater than that which could be maintained by mutation alone. A polymorphic locus is one at which there are at least two alleles,each with a frequency greater than 1%.Alleles with frequencies less than 1% are referred to as mutants (or rare variants). 12 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics Normal Variants and mutations Gene A Gene C(Polymorphic) Allele 1 (Normal)99.5% Allele 1 (Variant 1)45.5% Allele 2(Mutant)0.5% Allele 2(Variant 2)30% Allele 3 (Variant 3)15% Gene B(Polymorphic) Allele 4 (Mutant)0.2% Allele 1 (Variant 1)50% Allele 5(Mutant)0.3% Allele 2 (Variant 2)30% Allele 3 (Variant 3)20% This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information