痛觉的解剖生理基础 感受器和传入神经纤维 ■疼痛信号在脊髓中的传递 ■疼痛信号由脊髓传递入脑
◼ 感受器和传入神经纤维 ◼ 疼痛信号在脊髓中的传递 ◼ 疼痛信号由脊髓传递入脑 痛觉的解剖生理基础
感受器和传入神经纤维 FIRSTSTEP--Transduction the conversion of the energy from a noxious thermal, mechanical, or chemical stimulus into electrical energy(nerve impulses By one of the somatic sensory receptors called nociceptor伤害性感受器) ■高阈机械痛感受器(IM及多觉型痛感受器(PNN a Present in most body tissues, including skin, bone muscle, most internal organs, blood vessels, and the heart but not in the brain
感受器和传入神经纤维 ◼ FIRST STEP-----Transduction: the conversion of the energy from a noxious thermal, mechanical, or chemical stimulus into electrical energy (nerve impulses) ◼ By one of the somatic sensory receptors called （伤害性感受器） ◼ 高阈机械痛感受器(HTM)及多觉型痛感受器（PMN) ◼ Present in most body tissues, including skin, bone, muscle, most internal organs, blood vessels, and the heart, but not in the brain. nociceptors
Nociceptors are the free endings of (primary afferent) nerve fibers distributed throughout the periphery. A Nociceptor types Thermal Mechanical Polymodal Silent A8 fibers X C fiber
Nociceptors are the free endings of (primary afferent) nerve fibers distributed throughout the periphery
Hairy skin Glabrous skin Merkel's梅克尔触盘 disk Epidermis Epidermal- dermal border Free nerve ending Dermis Meissner corpuscle迈斯纳小体 Hair follicle eceptor Pacinian 环层小体 corpuscle Ruffini's ending
环层小体 迈斯纳小体 梅克尔触盘
Adequate Stimulation y Temperature(>50℃or<1℃) y Mechanical damage:强机械刺激,针尖刺敏感 y! Chemicals(released from damaged tissue)
Adequate Stimulation Temperature (>50℃ or <1 ℃) Mechanical damage：强机械刺激，针尖刺敏感 Chemicals (released from damaged tissue)