Cl C H Cl Cl Cl Cl Cl Si H Cl Cl Cl Cl DDT DDD Silane Analogs of DDT
Cl C H Cl Cl Cl Cl Cl Si H Cl Cl Cl Cl DDT DDD Silane Analogs of DDT
四川大学化学学院 2002年7月26日 27 Organosilane Fungicides ◼ As a novel entry into the class of triazole（三 唑） fungicides（防真菌剂） ◼ Moberg and coworkers prepared a series of silane analogs. One of these, flusilazole（氟苯 代硅三唑） proved to be a highly effective crop fungicide（谷类防真菌） and is now a major commercial product. ◼ Compound flusilazole is an inhibitor of sterol （固醇） biosynthesis, similar to other triazole fungicides. ◼ The properties of this compound responsible for its field performance, including volatility, solubility, and movement within plants, have been described
四川大学化学学院 2002年7月26日 27 Organosilane Fungicides ◼ As a novel entry into the class of triazole（三 唑） fungicides（防真菌剂） ◼ Moberg and coworkers prepared a series of silane analogs. One of these, flusilazole（氟苯 代硅三唑） proved to be a highly effective crop fungicide（谷类防真菌） and is now a major commercial product. ◼ Compound flusilazole is an inhibitor of sterol （固醇） biosynthesis, similar to other triazole fungicides. ◼ The properties of this compound responsible for its field performance, including volatility, solubility, and movement within plants, have been described
四川大学化学学院 2002年7月26日 28 Organosilane Fungicides ◼ The primary metabolite of flusilazole is the silanol, resulting from cleavage of the triazole-substituted methyl group from silicon. ◼ Presumably silanol has little or no biological activity, and the higher oxidation level silanol will enhance the rate of its further degradation (relative to flusilazole). ◼ Flusilazole is an excellent example of the commercial potential for biologically active organosilanes
四川大学化学学院 2002年7月26日 28 Organosilane Fungicides ◼ The primary metabolite of flusilazole is the silanol, resulting from cleavage of the triazole-substituted methyl group from silicon. ◼ Presumably silanol has little or no biological activity, and the higher oxidation level silanol will enhance the rate of its further degradation (relative to flusilazole). ◼ Flusilazole is an excellent example of the commercial potential for biologically active organosilanes
Flusilazole （氟苯代硅三唑） Metabolism Usage： crop fungicide
Flusilazole （氟苯代硅三唑） Metabolism Usage： crop fungicide
四川大学化学学院 2002年7月26日 30 ⚫ 4.1 Isosteric Replacement of Carbon with Silicon (用硅对碳进行等电排置换)in the Design of Safer Chemicals ⚫ 4.2 Designing Biodegradable Chemicals ⚫ 4.3 Designing Aquatically Safer Chemicals ⚫ References
四川大学化学学院 2002年7月26日 30 ⚫ 4.1 Isosteric Replacement of Carbon with Silicon (用硅对碳进行等电排置换)in the Design of Safer Chemicals ⚫ 4.2 Designing Biodegradable Chemicals ⚫ 4.3 Designing Aquatically Safer Chemicals ⚫ References