4.1.1 Silicon is an Isosteric atom of Carbon Organic derivatives of silicon and carbon generally have no intrinsic toxicity, in contrast with the other Group 4A elements germanium, tin, and lead. From a toxicity perspective, silicon is the only Group 4A element that is a suitable replacement for carbon. In addition, silicon is an abundant, inexpensive element and one that is available in a variety of forms
4.1.1 Silicon is an Isosteric atom of Carbon Organic derivatives of silicon and carbon generally have no intrinsic toxicity, in contrast with the other Group 4A elements germanium, tin, and lead. From a toxicity perspective, silicon is the only Group 4A element that is a suitable replacement for carbon. In addition, silicon is an abundant, inexpensive element and one that is available in a variety of forms
四川大学化学学院 2002年7月26日 7 The lifetime of organic silicon compounds is quite limited Insecticide (杀虫剂) Example Urethanes(尿烷), neutral analogs of the neuro-transmitter(神 经传递质)acetylcholine(乙酰胆碱)(1), were found to be antagonists(拮抗药)of (1) with identical dose-response curves . Interestingly, silane was much less toxic to mice than Urethane(carbon), and exhibited muscle relaxant properties
四川大学化学学院 2002年7月26日 7 The lifetime of organic silicon compounds is quite limited Insecticide (杀虫剂) Example Urethanes(尿烷), neutral analogs of the neuro-transmitter(神 经传递质)acetylcholine(乙酰胆碱)(1), were found to be antagonists(拮抗药)of (1) with identical dose-response curves . Interestingly, silane was much less toxic to mice than Urethane(carbon), and exhibited muscle relaxant properties
Acetylcholine(乙酰 胆碱) Urethane(尿烷) Muscarinic Antagonistis（ 蝇覃碱拮抗剂） O NH2 N O CH3 Si O NH2 O O O
Acetylcholine(乙酰 胆碱) Urethane(尿烷) Muscarinic Antagonistis（ 蝇覃碱拮抗剂） O NH2 N O CH3 Si O NH2 O O O
O NHCH3 O O NHCH3 Si O Carbamate Silicon substituted Isostere of carbamate (More degradable, less toxic to human and environment) Carbamate insecticide and its silicon analog were found to have similar toxicity to the house fly
O NHCH3 O O NHCH3 Si O Carbamate Silicon substituted Isostere of carbamate (More degradable, less toxic to human and environment) Carbamate insecticide and its silicon analog were found to have similar toxicity to the house fly
四川大学化学学院 2002年7月26日 10 ◼ In both of these examples, the tertbutyl and trimethylsilyl groups function simply as isosteres of trimethylammonium
四川大学化学学院 2002年7月26日 10 ◼ In both of these examples, the tertbutyl and trimethylsilyl groups function simply as isosteres of trimethylammonium