bronchial asthma
bronchial asthma
Introduction Bronchial asthma is a chronic inflammatory condition involving a variety of cells including eosinophils, mast cells, T lymphocytes, neutrophils, and epithelial cells of the airway, as well as cellular elements, which gives rise to the increase of airway hyper-reactivity. Extensive changeable and reversible ventilation restriction is common and can cause recurrent tachypnea, feeling of out of breath, and coughing. The symptoms are more usually present and aggravated at night or early in the morning. Remission might be achieved spontaneously or following treatment
Introduction Bronchial asthma is a chronic inflammatory condition involving a variety of cells including eosinophils, mast cells, T lymphocytes, neutrophils, and epithelial cells of the airway, as well as cellular elements， which gives rise to the increase of airway hyper-reactivity. Extensive changeable and reversible ventilation restriction is common and can cause recurrent tachypnea, feeling of out of breath, and coughing. The symptoms are more usually present and aggravated at night or early in the morning. Remission might be achieved spontaneously or following treatment
etiology The pathogenesis of asthma is complicated and is affected by genetics and the environment. It is a multigene disoder and closely related to atopy. Most patients have prior history of eczema, allergic rhinitis food or drug allergy, and quite a few patients have family history. The formation and attack of asthma is also a consequence of the function of multiple environmental factors such as inhalation of allergens respiratory tract infection, and coldness
etiology The pathogenesis of asthma is complicated and is affected by genetics and the environment. It is a multigene disoder and closely related to atopy. Most patients have prior history of eczema, allergic rhinitis, food or drug allergy, and quite a few patients have family history. The formation and attack of asthma is also a consequence of the function of multiple environmental factors such as inhalation of allergens, respiratory tract infection, and coldness
epidemology 160 million patients in the word prevalence: 1%--5%,1% in china Prevalence in male is similar to that in female The onset is before 12 years of age in the majority Family history could be found in 20% patients Related to allergic rhinitis, eczema and nasal polyp
epidemiology • 160 million patients in the word • prevalence：1%--5%，1% in china • Prevalence in male is similar to that in female • The onset is before 12 years of age in the majority • Family history could be found in 20% patients • Related to allergic rhinitis, eczema and nasal polyp
etiology 1. Genetic factors: multigene inheritance heritability 70-80% 2. Predisposing factors: air pollution 1)inhalants: dust mites, pollen 2)infections food 4)change of weather 5)mental factors 6) exercise运动 7)drugs menstruation, pregnacy
etiology • １．Genetic factors: multigene inheritance heritability 70-80% • ２．Predisposing factors: air pollution 1） inhalants：dust mites、pollen 2） infections 3） food 4） change of weather 5） mental factors 6） exercise运动 7） drugs 8） menstruation, pregnacy