Arterial pulse recorded under Systolic Diastolic pressure pressure different conditions Normal G160 Arteriosclerosis 120 工EEo5009 Patent ductus arteriosus or moderate aortIc 80 regurgitation 040812162024 Seconds
Arterial pulse recorded under different conditions 16
Blood travels from artery to arteriole to capillary to venule to vein Blood Travels from Artery to Arteriole to Capillary to Wente y ein animated b Blood flow Dawn A. Tamarkin Ph. D Blood flow
• Blood travels from artery to arteriole to capillary to venule to vein 17
Arterioles(微动脉) Two major roles To be responsible for determining the relative blood flow in individual organs at any given MAP o All together, to be a major factor in determining MAP Arteriole Small Arterioles Nd frege Th erce, by sN a epmI N2 ihw aewin grop,be Smooth muscle cell Endothelin
Arterioles（微动脉） Two major roles: • To be responsible for determining the relative blood flow in individual organs at any given MAP •All together, to be a major factor in determining MAP 18
Arterioles Small precapillary resistance vessels(10-50 p) composed of an endothelium surrounded by one or more layers of smooth muscle cells Richly innervated by sympathetic adrenergic fibers and highly responsive to sympathetic vasoconstriction via both a l and a2 adrenergic receptors Represent a major site for regulating systemic vascular resistance Primary function within an organ is filow regulation, thereby determining oXygen delivery and the washout of metabolic by-products Regulate, in part, capillary hydrostatic pressure and therefore influence capillary fluid exchange
Arterioles • Small precapillary resistance vessels (10-50 μ) composed of an endothelium surrounded by one or more layers of smooth muscle cells • Richly innervated by sympathetic adrenergic fibers and highly responsive to sympathetic vasoconstriction via both α1 and α2 adrenergic receptors • Represent a major site for regulating systemic vascular resistance • Primary function within an organ is flow regulation, thereby determining oxygen delivery and the washout of metabolic by-products • Regulate, in part, capillary hydrostatic pressure and therefore influence capillary fluid exchange 19
Effects of arteriolar vasodilation or vasoconstriction on capillary blood pressure Copyright e The McGraw-Hill Companies, Inc. Permission required for reproduction or display 110 Artery Arteriole Capillary 100 Vasodilation 80 ①50 60 40 Initial state Qm Vasoconstriction 20 Distance along systemic blood vessels Dynamic changes in vasodilation/vasoconstriction in the arterioles regulate downstream pressures and flow rates
Dynamic changes in vasodilation/vasoconstriction in the arterioles regulate downstream pressures and flow rates. Effects of arteriolar vasodilation or vasoconstriction on capillary blood pressure 20