ReferencesThe ion channel factsbook:Voltage-gated channels,Edward CConley, W. J. Brammar - 1999 - 860 pageslonchannelsandgeneticdiseases,DavidC.Dawson,SocietyofGeneralPhysiologists.Symposium,RaymondA.Frizzell-1995-178pagesLigand-and voltage-gatedion channels,R.AlanNorth-1995349pageslonchannelsofexcitablemembranes,BertilHille-2001-814pagesAxon_Guide.pdfEurBiophysJ2004,33,211-26ionchannels.pdfJMolCellCardiol2010,48,65-70CardiacCachannel.pdfPflugersArch-EyrJPhysiol2oo9,CardiacNachannel.pdfNatureRevNeurosci2007,8,451-65AP.pdfTrendsinNeuroscience2009,32,215-24TRPVchannel.pdf
References The ion channel factsbook: Voltage-gated channels , Edward C. Conley, W. J. Brammar - 1999 - 860 pages Ion channels and genetic diseases , David C. Dawson, Society of General Physiologists. Symposium, Raymond A. Frizzell - 1995 - 178 pages Ligand- and voltage-gated ion channels , R. Alan North - 1995 - 349 pages Ion channels of excitable membranes , Bertil Hille - 2001 - 814 pages Axon_Guide.pdf Eur Biophys J 2004, 33, 211-26 ion channels.pdf J Mol Cell Cardiol 2010, 48, 65-70 Cardiac Ca channel.pdf Pflugers Arch-Eyr J Physiol 2009, Cardiac Na channel.pdf Nature Rev Neurosci 2007, 8, 451-65 AP.pdf Trends in Neuroscience 2009, 32, 215-24 TRPV channel.pdf
ReferencesKartikVenkatachalam,CraigMontell(2007)TRPChannels.AnnualReviewofBiochemistry,76:387-417ProgressBiophysicsMoleBio2009,99,7-19NatRevDrugDiscov2009,8,153-71神经系统离子通道病，张黎明，科学出版社，2008年，465页离子通道学，李决、程芮，湖北科学技术，2007年，527页实用膜片钳技术，刘振伟编著，军事医科出版社，2006年心肌细胞离子通道和通道病，刘泰编著，人民卫生出版社，2006年离子通道药理学，杨宝峰主编，人民卫生出版社，2005年膜片钳实验技术，陈军，电子书心肌细胞电生理学：离子通道，离子载体和离子流，刘泰编著，人民卫生出版社，2005，252页细胞膜离子通道，刘安西，陈守同编译，中央民族学院出版社，1990年离子通道与疾病，张宗明，裘法祖.世界华人消化杂志，2005，13：585587
References Kartik Venkatachalam, Craig Montell (2007) TRP Channels. Annual Review of Biochemistry, 76: 387-417 Progress Biophysics Mole Bio 2009, 99, 7-19 Nat Rev Drug Discov 2009, 8, 153-71 神经系统离子通道病, 张黎明, 科学出版社, 2008 年, 465 页 离子通道学, 李泱、程芮, 湖北科学技术, 2007 年, 527 页 实用膜片钳技术, 刘振伟 编著, 军事医科出版社, 2006 年 心肌细胞离子通道和通道病, 刘泰槰编著, 人民卫生出版社, 2006 年 离子通道药理学, 杨宝峰 主编, 人民卫生出版社, 2005 年 膜片钳实验技术, 陈军, 电子书 心肌细胞电生理学：离子通道，离子载体和离子流, 刘泰槰编著, 人民 卫生出版社, 2005, 252 页 细胞膜离子通道, 刘安西，陈守同编译, 中央民族学院出版社, 1990 年 离子通道与疾病, 张宗明, 裘法祖. 世界华人消化杂志, 2005, 13: 585- 587
Vital roles ofionchannelsInbasicphysiologicalfunctionsgeneration of electrical activity in nerves and musclecontrol of cardiac excitabilityintracellularsignalinghormonesecretioncell proliferationcellvolume regulationmanyotherbiologicalprocessesInanumberofpathophysiologicalconditionsepilepsyepisodicataxialongQTsyndromeBartter'ssyndromecysticfibrosis
Vital roles of ion channels In basic physiological functions generation of electrical activity in nerves and muscle control of cardiac excitability intracellular signaling hormone secretion cell proliferation cell volume regulation many other biological processes In a number of pathophysiological conditions epilepsy episodic ataxia long QT syndrome Bartter’s syndrome cystic fibrosis
Vital roles of ionchannelslon channels are drug targets fora number oftherapeutic agents developed forthe treatment ofvariousdiseasesNatchannel blockerssuchaslidocaineandlamotrigine are used as local anesthetic and to treatepilepsy,respectivelyCalciumchannel blockers suchas verapamil andnifedipine are usedforthetreatment of cardiacarrhythmiasandhypertension·ATP-dependentK+channelinhibitorssuchastolbutamide and glibenclamideareeffective inthetreatmentoftypell diabetes
Vital roles of ion channels Ion channels are drug targets for a number of therapeutic agents developed for the treatment of various diseases. Na+ channel blockers such as lidocaine and lamotrigine are used as local anesthetic and to treat epilepsy, respectively Calcium channel blockers such as verapamil and nifedipine are used for the treatment of cardiac arrhythmias and hypertension ATP-dependent K+ channel inhibitors such as tolbutamide and glibenclamide are effective in the treatment of type II diabetes
Thehistoryof ionchannelWenowknowthat,ionsarenotonlypossible,butacommon everyday experience,especiallyinaqueoussolutions such as those which surround living cells.Theconcept of an ion channelhadto await the acceptance bythe scientific community of the existence of ions as wellas the notion that cells are surrounded by a fattymembranebilayer.Thelate170s,Lavisouirandothers,physics,chemistryandbiologyTheemergenceofbothionandcell membraneconceptscanbetracedbacktothelate18o0s
The history of ion channel We now know that, ions are not only possible, but a common everyday experience, especially in aqueous solutions such as those which surround living cells. The concept of an ion channel had to await the acceptance by the scientific community of the existence of ions as well as the notion that cells are surrounded by a fatty membrane bilayer. The late 1700s, Lavisouir and others, physics, chemistry and biology The emergence of both ion and cell membrane concepts can be traced back to the late 1800s