《离子通道生物学》课程教学课件（英文讲稿）Ca2+ channels

Classification of voltagegated Ca2+ channels

Classification of voltage￾gated Ca2+ channels

(B)(A)+++++++++++++++++++++++++++++++++++++十+GateS4 helixCytoplasm2001SinauerAssociates,Inc

ClosedOpenA Ligand-gatedCa2+ channeltypesBind ligandExtracellularsideVoltageoperatedCa2+channels(VOCCytoplasmicsideB Phosphorylation-gatedLigandoperatedCa2+channel(LOC)PhosphorylateReceptorOperated (ROCs):DirectlyActivated byAgonistsNicotinicAcidReceptor(Nat)ExtracellularATPChannel(Cation)DephosphorylateON-methyl-D-aspartate (Glutamate) Channel (Ca+). Voltage-gatedChangeActivated by SolubleSecondMessengerOperated(SMOC):membranepotentialIP,-Sensitive ChannelSecond Messengers.Ca2+Induced Ca2+releaseG-protein Operated (GOCs).Insulin-likeGrowthFactor2(IGF-2);(Ca2+)N-methyl-D-aspartate(NMIDA)DStretchorpressure-gatedStretch

Ca2+ channel types  Voltage operated Ca2+ channels (VOC)  Ligand operated Ca2+ channel (LOC)

Ca2+current typesDefined by physiological and pharmacologicalcriteria·L-typeCa2+currents·T-typeCa2+currentsN-typeCa2+currents·P-typeCa2+currents.Q-typeCa2+currents●R-typeCa2+currents

Ca2+ current types Defined by physiological and pharmacological criteria  L-type Ca2+ currents  T-type Ca2+ currents  N-type Ca2+ currents  P-type Ca2+ currents  Q-type Ca2+ currents  R-type Ca2+ currents

HistoricaldevelopmentofVACCsNomenclatureNomenclatureStructuralaccording to 2,3nomenclature4according to 1Cav1.1aisCav1.2aicL-typeCay1.3QiDCay1.4Q1FHVAchannelsP/Q-typeCav2.1Q1ANeuronalN-typeCav2.2Q1BR-typeCay2.3QiECav3.1Q1GT-typeLVAchannelsCay3.2QiHCav3.3α111 Tsien et al. (1988); 2 Snutch et al. (1990); 3 Birnbaumer et al. (1994); 4 Ertel et al.(2000)

Historical development of VACCs