Diagnosis a The dsm-iv and icd-10 have defined subtypes of schizophrenia Paranoid type -only with delusions and hallucinations Disorganized type -thought d/o and flat affect are present at the same time Catatonic -immobile or have purposeless movement Undifferentiated type- psychotic Sx are present, but above not met Residual type -Sx are present, but with low intensity Post-schizophrenic depression Simple schizophrenia- progressive development of negative Sx with no prior psychotic episodes
The DSM-IV and ICD-10 have defined subtypes of schizophrenia: ◼ Paranoid type - only with delusions and hallucinations ◼ Disorganized type - thought d/o and flat affect are present at the same time ◼ Catatonic type - immobile or have purposeless movement ◼ Undifferentiated type - psychotic Sx are present, but above not met ◼ Residual type - Sx are present, but with low intensity ◼ Post-schizophrenic depression ◼ Simple schizophrenia- progressive development of negative Sx with no prior psychotic episodes
Who is most at risk to have Schizophrenia? a Family history or ties to schizophrenia 口 Prenatal problems e.g., mother was malnourished, had viral infection, took medications (diuretics, etc) a Family member has history of psychotic disorder (such as delusional disorder) a You have problems with drug or alcohol Shizophrenia causes problems? Problems cause schizophrenia? 口 Age of onset: Late adolescence and early adulthood
Family history or ties to schizophrenia Prenatal problems ◼ e.g., mother was malnourished, had viral infection, took medications (diuretics, etc) Family member has history of psychotic disorder (such as delusional disorder) You have problems with drug or alcohol ◼ Shizophrenia causes problems? ◼ Problems cause schizophrenia? Age of onset: ◼ Late adolescence and early adulthood
What causes Schizophrenia? 口 Dopamine imbalance This is the most commonly researched a Genetics (our focus) a Prenatal and early environment 口 Neurobiology a All factors interact to trigger the manifestation of schizophrenia
Dopamine imbalance ◼ This is the most commonly researched Genetics (our focus) Prenatal and early environment Neurobiology All factors interact to trigger the manifestation of schizophrenia
Possible causes of Schizophrenia: A Comparison Odds Ratio 0 3 5 6 8 910 Place/time of birth Winter Urban Influenza Respiratory Infection Rubella Poliovirus CNS Famine Bereavement Prenatal Flood Unwantedness Maternal depr Rh incompatibility Hypoxia Obstetric CNS damage Low birth weight Pre-eclampsia Family history