(二)细胞皮层 10 um
（二）细胞皮层
(三)应力纤维 Actin stress fibers(red)terminate in focal adhesions (green).Nucleiare in blue http://jcb.rupress.org/content/196/1/4
（三）应力纤维 Actin stress fibers (red) terminate in focal adhesions (green). Nuclei are in blue http://jcb.rupress.org/content/196/1/4
(四)细胞伪足的形成与细胞迁移 应力纤维 细胞皮层 丝状伪足 紧 A 反向排列的收缩束 凝胶样网络 同向紧密排列的平行束
（四）细胞伪足的形成与细胞迁移
Cell crawling Focal Direction of movement adhesion ●细胞运动过程中 7777777777777 力产生机制 Extension >微丝装配将质膜 actin Lamellipodium 向前推进 myosin 777M >yosin和Actin Adhesion 相互作用 New adhesion 7777777777777777707777777770777777777777 3Translocation Cell body movement- De-adhesion and endocytic recycling Old adhesion Figure 17-38 Molecular Cell Biology.Sixth Edition 2008W.H.Freeman and Company Figure 16-91 Molecular Biology of the Cell(Garland Science 2008)
Cell crawling Figure 16-91 Molecular Biology of the Cell (© Garland Science 2008) ⚫细胞运动过程中 力产生机制 ➢微丝装配将质膜 向前推进 ➢Myosin和 Actin 相互作用
Cell crawling Direction of cell fragment movement Elastic membrane Retraction Protrusion Gradient of F-actin density Old New adhesion adhesion Substrate http://ww.pnas.org/content/108/51/20275/F1.large.jpg
Cell crawling http://www.pnas.org/content/108/51/20275/F1.large.jpg