Acetylcholine ● Nicotinic receptors Nm(muscular-type or n2): skeletal muscle Nn(neuron-type, or Ni: autonomic ganglia CNS o Muscarinic receptors Postganglionic parasympathetic and a few sympathetic sites, CNs(also autonomic gang Receptor subtypes: Mi-5
Acetylcholine ⚫ Nicotinic receptors – Nm (muscular-type or N2 ): skeletal muscle – Nn (neuron-type, or N1 ): autonomic ganglia, CNS ⚫ Muscarinic receptors – Postganglionic parasympathetic and a few sympathetic sites, CNS (also autonomic gang.) – Receptor subtypes: M1-5
Catecholamines ● Norepinephrine Postganglionic sympathetic, CNS, adrenal medulla Receptors:c1,x2,阝1 ● Epinephrine Adrenal medulla CNS Receptors:a12a2,β1,β2 ● Dopamine Autonomic ganglia, CNS Receptors: D 1-5)
Catecholamines ⚫ Norepinephrine – Postganglionic sympathetic, CNS, adrenal medulla – Receptors: a1 , a2 , b1 ⚫ Epinephrine – Adrenal medulla, CNS – Receptors: a1 , a2 , b1 , b2 ⚫ Dopamine – Autonomic ganglia, CNS – Receptors: D(1-5), a1 , b1
Location of aNs receptors Copyright e The McGraw-Hill Companies, Inc. Permission requred for reproduction or display Sympathetic division Most target tissues innervated by the Cell of target tissue sympathetic division have adrenergic ACh Location receptors. When norepinephrine(NE) released of adrenergic binds to adrenergic receptors, some receptors target tissues are stimulated, and Location others are inhibited. For example of nicotinic NE released smooth muscle cells in blood vessels are stimulated to constrict, and receptors stomach glands are inhibited Preganglionic neuron Postganglionic neuron Sympathetic division Some sympathetic target tissues, Location such as sweat glands, have muscarinic receptors, which respond to acetylcholine(ACh). Stimulation of sweat glands results in increased 米冰 of muscarinic receptors sweat production ACh released released Cell of target tissue Preganglionic neuron Postganglionic neuron Parasympathetic division All parasympathetic target tissues Cell of target tissue have muscarinic receptors. The Location general response to ACh is excitatory, but some target tissues, such as the heart, are inhibited 米 of muscarinic ACh receptors released Location of nicotinic receptors ACh released Preganglionic neuron Postganglionic neuron
Location of ANS Receptors