gain- of-function突变原癌基因突变称癌基因 瘟基因: · Growth factors Growth factor receptors Signal tranductors Nuclear transcription factors Cell cycle requlators Apoptotic resistant factors
gain-of-function 突变:原癌基因突变称癌基因 癌基因： • Growth factors • Growth factor receptors • Signal tranductors • Nuclear transcription factors. • Cell cycle regulators • Apoptotic resistant factors
→原癌基因与癌发生 Virus-encoded activators of s D- Growth factor (I Growth factor receptor (Il) Intracellular effector Intracellula regio transducers Intracellular Second messengers ( phosphorylated proteins) NUCLEUS Transcription factors (Iv) DNA-repair DNA oooooood poore proteins /v/l Transcription Cell-cycle control proteins (VI) RNA⌒⌒⌒ mRNA Anti-apoptosis Proteins proteins (V)
原癌基因与癌发生