认识胰岛-组织结构 Close up wew of细胞群 Islet of Langerhans D Ceila Cell α细胞20%胰高血糖素 Red Bcod Pancrea β细胞65%胰岛素 V细胞10%生长抑素 islet of angerhans PP细胞5%胰多肽 1869年发现由德国病理学家保罗·兰格尔翰斯( Langerhans)
认识胰岛-组织结构 细胞群 α细胞 20% 胰高血糖素 β细胞 65% 胰岛素 γ细胞 10% 生长抑素 PP细胞 5% 胰多肽 1869年发现由德国病理学家保罗·兰格尔翰斯（Langerhans）
INS 18s GLU 19 m; insulin 90% dorsal 工NS828 pancreatic peptide ● SST somatostatin ● GH ghrelin human ①s:4 Blood vessel Suckale et al.2008,而g,2]G日1告? pancreatic duct Body of pancreas Minor duodenal papila Hepatopancreatic ampulla Major duodenal papilla Pancreatic duct Plicae circulares A Head of pancreas
Pancreatic beta cells( cells)are known to be sensitive to glucose concentrations in the blood The human insulin protein is composed of 51 amino acids and has a molecular mass of 5808 Da insulin 1 3 glucose transporter-4, insulin receptor gly 4 ○ fatty acic ivate
The human insulin protein is composed of 51 amino acids, and has a molecular mass of 5808 Da Pancreatic beta cells (β cells) are known to be sensitive to glucose concentrations in the blood
认识胰岛胰岛素合成与分泌过程 VDC Channel K.--Channo Glucose (…a GLUT2 胃肠激素(+) ○ ATPIADP↑ 胰高血糖素(+) nL Proinsulin s delved 8、 cols> Glucose to foa e b mature 氨基酸(+) hain and C-pectde ptry gras t Activation of 生长抑素(-) certain kinases (PI3-K ERK1/2. IL Rainsun (TGN) SAPK/p38) i wanaporsd rER O Loob L Preproinsulin yanshen, sond s Apparatus Activation of factors involved elF2 and elF4F in insuin actaeon transcription PDX-1.E47, dne Beta2. MaMA 基础研究:分泌环节有哪些!调控环节有哪些?
认识胰岛 胰岛素合成与分泌过程 胃肠激素（+） 胰高血糖素（+） 氨基酸（+） 生长抑素（-） 基础研究：分泌环节有哪些！调控环节有哪些？