HR Barororeflex Sensitivity In(Max Am plitude)of APB->HRT urIne Standin Pre-Bedrest End-Bedrest Post-Bedrest -040 -0.6 百 0.80 140 -1.60 P hase
HR Barororeflex Sensitivity
Effect of midodrine Pre-Bedrest Post w/o Midodrine Post with midodrine HR in beats/min HR in beats/min HR in beats/min BP in mmHg BP in mmhg BP in mmhi 5 152025
Effect of Midodrine
100 P=0.021 G90 80 Midodrine 570 60 50 d40 o30 c20 Control 10 04080120160 Time(Minutes)
Kaplan-Meier Syncope-Free Survival 0 40 80 120 160 0 10 20 30 40 50 60 70 80 90 100 Con trol Midodrine P = 0.021 Time (Min u tes) Syncope-Free Survival
Arrhythmias in Space Anecdotal reports of ventricular arrhythmias during spaceflight Runs of ventricular tachycardia recorded from members of Skylab and Mir Two Russian Mir cosmonauts reportedly brought back early due to heart rhythm disturbances Two primates died suddenly following landing No deaths from ventricular arrhythmias during space flight
Arrhythmias in Space • Anecdotal reports of ventricular arrhythmias during spaceflight • Runs of ventricular tachycardia recorded from m e mbers of Skylab and Mir • Two Russian Mir cosmonauts reportedly brought back early due to hea rt rhythm disturbances • Two primates died suddenly following landing • No deaths from ventricular arrhythmias during space flight
Arrhythmias in Space It is not known whether or not spaceflight increases the risk of ventricular arrhythmias If spaceflight does increase the risk of ventricular arrhythmias. it could be of concern for long term space flight such as during a mission to mars
Arrhythmias in Space • It is not known whether or not s paceflight increases the ris k of ventricular arrhythmias. • If s pacefl ight does increase the risk of ventricul ar arrhythmi as, it could be of concern for long term space flight such as during a mission t o Mars