Effects of Microgravity on Cardiovascular Hormonal and Renal response to posture Investigators Richard Cohen. M.D. Ph. D Craig Ramsdell, MD Tom mullen ph D Natalie Sheynberg, M D Gordon Williams, MD Disciplines: Cardiology, Endocrinology, Space Medicine Primary Source National Space Biomedical Research of Funding: Institute GCRC Site Visit
Effects of Microgravity on Cardiovascular, Hormonal and Renal Response to Posture Investigators: Richard Cohen, M.D., Ph.D Craig Ramsdell, M.D., Tom Mullen, Ph.D., Natalie Sheynberg, M.D. Gordon Williams, M.D. Disciplines: Cardiology, Endocrinology, Space Medicine Primary Source National Space Biomedical Research of Funding: Institute GCRC Site Visit
Experiment Protocol 2 Days 16 Days 3 Days Extensive 4°HDT Extensive cV& Endocrine Bed rest cV& Endocrine Testing Testing Controlled Diet, NA, K and Fluid Intae/ Supine-Stand Tests Cardiovascular System d All Infusions T Wave alternans Electrolytes eg Compliance studies Norepi infusions Echocardiograms Others
Experiment Protocol 2 Days Extensive CV & Endocrine Testing 3 Days Extensive CV & Endocrine Testing 16 Days 4º HDT Bed rest Controlled Diet, NA, K and Fluid Intake • Supine-Stand Tests • Cardiovascular System ID • AII Infusions • T W ave Alternans • Ele c trolytes • Leg Compliance S tudies • Norepi Infusions • Echocardiograms • Others
Cardiovascular System Identification System Identification Results ABP ECG r ILV (Respitrace Amplifier A/D System Identification
Cardiovascular System Identification S ystem Identification Res ults ABP (Finapres) ECG A/D (Respitrac e) ILV A mplifier System Identificatio n
N ILV-+HR 00a1020.30405 BAROREFLEX CSI Autonomic Activity (Heart Rate Tachogram) Effect of SA NODE ILV Atrio-Ventricular Activation (mpule Heart Rate) Autonomic 000.102030405 CIRCULATORY MECHANIC Blood Pressure Blockade ILV-+ABP
CSI Effect of Autonomic Blockade
ILV-+HR BAROREFLEX CSI Autonomic Activity (Heart Rate tache Effect of SA NODE Autonomic (Impulse Heart Rate CIRCULATORY MECHANIC Arte Neuropathy LLv→ABP ABP 000.10.2030405
CSI Effect of Autonomic Neuropathy