母体内的IgG与胎 儿体内的Rh抗原 结合,导致胎儿出 生后发生新生儿溶 血症
母体内的IgG与胎 儿体内的Rh抗原 结合，导致胎儿出 生后发生新生儿溶 血症
3. Autoimmune hemolytic disease Some drugs or viruses stimulate Ab formation by changing the erythrocyte surface components to form new epitopes. The resulting Abs can cross react with epitopes on unmodified RBCs
3. Autoimmune hemolytic disease Some drugs or viruses stimulate Ab formation by changing the erythrocyte surface components to form new epitopes. The resulting Abs can cross react with epitopes on unmodified RBCs
Mechanisms Clinicopathologic Disease Target antigen of disease manifestations hemolytic anemia proteins(Rh blood group phagocytos(and Autoimmune Erythrocyte membrane Opsonization Hemolysis, anemia antigens, I antigen) of erythrocytes Autoimmune Platelet membrane Opsonization and Bleeding (idiopathic) proteins(gpllb: lla phagocytos thrombocytopenic integrin) of platelets purpura Pemphigus Proteins in intercellular Antibody-mediated Skin vesicles vulgarIs junctions of epidermal activation of proteases,(bullae) cells(epidermal cadherin) disruption of intercellular adhesions Goodpastures Noncollagenous protein Complement- and Nephritis. syndrome in basement membranes Fc receptor-mediated lung hemorrhages of kidney glomeruli and inflammation lung alveoli Acute rheumatic Inflammation Myocarditis fever macrophage activatio antigen Myasthenia gravis Acetylcholine receptor Antibody inhibits Muscle weakne acetycholine binding lysis down-modulates receptors Graves disease Thyroid-stimulating Antibody-mediated Hyperthyroidism (hyperthyroidism) hormone(TSH)receptor stimulation of TSH receptors Pernicious anemia Intrinsic factor of gastric Neutralization of Abnormal parietal cells intrinsic factor decreased absorption anemia 2 @ElsevierAbbas&Lichtman:BasicImmunologyUpdated2e-www.studentconsult.com Human antibody-mediated diseases
Human antibody-mediated diseases
4. Drug-induced reaction to blood components These diseases have been associated with many different chemotherapeutics, such as penicillin, the sulfonamides. These drugs stimulate Ab formation by forming new epitopes with serum proteins which then adsorb nonspecifically to the red blood cell surface so that its new epitopes are expressed
4. Drug-induced reaction to blood components These diseases have been associated with many different chemotherapeutics, such as penicillin, the sulfonamides. These drugs stimulate Ab formation by forming new epitopes with serum proteins, which then adsorb nonspecifically to the red blood cell surface so that its new epitopes are expressed
5 Graves' disease The patients produce antibodies to thyrotropin (thyroid stimulating hormone, TsH receptor. The end result is overproduction of thyroid hormone and hyperthyroidism
5. Graves’ disease The patients produce antibodies to thyrotropin (thyroid stimulating hormone, TSH) receptor. The end result is overproduction of thyroid hormone and hyperthyroidism