a. chief (zymogenic) cells胃小叫Gastric pitDistribution: predominate in thegland baseLM:basophilic base cytoplasm,and颈部Theneckpale-staining apical cytoplasmcontaining secretory granules.体部EM:typical appearance ofaThe bodyprotein-secreting cellFunction:Secreteinactiveprotei胃底腺Fundicglandpepsinogen.npeptidpepsin庭部The base粘膜肌层Muscularis11mucosae胃底腺（纵切）H·E低信Fundic gland (longitudinal section)
a. chief (zymogenic) cells Distribution: predominate in the gland base LM: basophilic base cytoplasm, and pale-staining apical cytoplasm containing secretory granules. EM: typical appearance of a protein-secreting cell 11 Function: Secrete inactive pepsinogen. pepsin HCL protei n peptid e
umeGolgiNucleusMitochondriaGolgicomplexRERsecretory granules12
12 Golgi complex RER secretory granules
b.parietal (oxyntic) cells胃小凹Gastric pitDistribution: present mainly at theupperhalf of the glands颈部The neckLM: round or pyramidal, 1 or 2体部centrallyThe bodyplaced spherical nucleus,strong acidophilic cytoplasm胃底腺Fundicgland庭部The base粘膜肌层Muscularis13mucosae胃底腺（纵切）H·E低信Fundic gland (longitudinal section)
b. parietal (oxyntic) cells Distribution: present mainly at the upper half of the glands. LM: round or pyramidal, 1 or 2 centrally placed spherical nucleus, 13 strong acidophilic cytoplasm
IntracellularcanaliculusabundantMT andIntracellularcanaliculi lined bymicrovilli(Activestate)tubulovesicularsystem(Restingstate)Function: secrete hydrochloric acid and gastric14intrinsicfactor
abundant MT and Intracellular canaliculi lined by microvilli (Active state) 14 tubulovesicular system (Resting state) Function: secrete hydrochloric acid and gastric intrinsic factor