Renin-Anyioiensin-Aldusisrone Sysiem o Very potent vasoconstrictor o Infusion of non- pressor doses of angiotensin ll increase blood pressure o Potent growth factor for smooth muscle cells C Clinical studies with drugs interfering with the system are very effective in lowering blood pressure o Interacts with other vasoconstrictor systems
The Renin-Angiotensin System Pathway CE Angiotensin I (10aa) Angiotensinogen Angiotensin ll (8aa) Angiotensin Receptor VvU Renin Stimulus Low salt intake Low blood volume Sodium retention silow blood pressure Vasoconstriction
Dr. Sica 24 ACE Renin Angiotensinogen Angiotensin I (10 aa) Angiotensin II (8 aa) Stimulus Angiotensin Receptor Low salt intake Low blood volume Low blood pressure Sodium retention Vasoconstriction The Renin-Angiotensin System Pathway
Incidence of CV Complications As a Function of Plasma renin Activity in Hypertension 25 20 15 I LVH Incidence I Stroke M Low Normal Hic Plasma Renin Activity Brunner HR et al. N Eng/J Med. 1972: 286: 441-449
0 5 10 15 20 25 Low Normal High LVH Stroke M I Incidence (%) Plasma Renin Activity Brunner HR et al. N Engl J Med. 1972;286:441-449. Incidence of CV Complications As a Function of Plasma Renin Activity in Hypertension
Paihophysioloyisll Aspsyiy oi Primry hypertension ◆ Salt and the kidney o Sympathetic nervous system O Renin-Angiotensin-Aldosterone System C Hemodynamics and structural changes ◆ Endothelial factors
Structural Ryiniortymsni: a Long Loop of th Syupithigfit-Anyioterisin Sysres Interaction Angiotensin BP Vascular hypertrophy Othar factore sympathetic Trophic ET-1, PDCF. ete effecte tone Ju:.2001