HIV病毒的生活周期 Chemokine CD4 coreceptor (w GAAAAA D...ARN o evelope O
16 HIV病毒的生活周期
吸附与穿入 糖蛋白gp120 近1%的高加索人因为 先与受体( receptor)CD4分子结合CR5基因中32个碱基缺 失使得细胞表面无CCR5 完整表达,从而不易感染 再与辅助受体(co- receptor) HIV。 CD4+T为CXCR4 巨噬细胞为CCR5 包膜蛋白构形改变Hv gp 脱离融合蛋白gp41 gp120 gp120 CD4 CXCR4 CXCR4 包膜和细胞膜融合,HIV gp41 进入细胞 CD4
吸附与穿入 糖蛋白gp120 先与受体(receptor)CD4分子结合 再与辅助受体(co-receptor)： CD4+ T为CXCR4 巨噬细胞为CCR5 包膜和细胞膜融合, HIV 进入细胞 包膜蛋白构形改变 脱离融合蛋白gp41 近1%的高加索人因为 CCR5基因中32个碱基缺 失使得细胞表面无CCR5 完整表达，从而不易感染 HIV
膜融合 B c Viral membrane gp conformational ance CD4 CCR5 or binding CXCR4 hees- Cell membrane E ding gp41 Membrane conformational chang
膜融合
穿入与脱壳 Chemo In the case of hiv forece virus entry(step 2 )is a pH-independent process that occurs after the fusion of vira and cellular ⊙ membranes and results in the partial uncoating(step 3 ) of Incoming virions
19 In the case of HIV, virus entry (step 2) is a pH -independent process that occurs after the fusion of viral and cellular membranes and results in the partial uncoating (step 3) of incoming virions. 穿入与脱壳
逆转录-入核一整合 Reverse transcription occurs within subviral particles in the cytoplasm of infected cells (step 4), and the double stranded dNA product within this preintegration complex Ye (PIC)is transported into the w nucleus(step 5),where integration into chromosomal DNA (step 6)is mediated by Envelc the virus-encoded integrase (IN)
20 Reverse transcription occurs within subviral particles in the cytoplasm of infected cells (step 4), and the double - stranded DNA product within this preintegration complex (PIC) is transported into the nucleus (step 5), where integration into chromosomal DNA (step 6) is mediated by the virus -encoded integrase (IN) . 逆转录 -入核 -整合