malignant blood disorders HSC differentiation is blocked Normal blood cells are decreased and leukemia cell is increased The function of blood and immune system are short of Fever, bleeding, anemia 2021/2/21 xie Yi, Hua Shan Hospital 6
2021/2/21 xie Yi,Hua Shan Hospital 6 malignant blood disorders HSC differentiation is blocked. Normal blood cells are decreased and leukemia cell is increased. The function of Blood and immune system are short of. Fever ，bleeding ，anemia
malignant blood disorders Proliferation is out of control apoptosis is inhibited and leukemia cell is accumulated in a great quantity. Leukostasis(白细胞淤滞) Abnormal morphology pictures of blood and bone marrow Liver, spleen, lymph nods, skin, CNS are infiltrated and dysfunctional frequently. 2021/2/21 xie Yi, Hua Shan Hospital 7
2021/2/21 xie Yi,Hua Shan Hospital 7 malignant blood disorders Proliferation is out of control ,apoptosis is inhibited and leukemia cell is accumulated in a great quantity. Leukostasis(白细胞淤滞) Abnormal morphology pictures of blood and bone marrow Liver,spleen,lymph nods, skin,CNS are infiltrated and dysfunctional frequently
the tradition classification(FAB)of leukemia According to the acute myeloid leukemia (AML) Differentiation& Mo M1 M2 M7 Kind of ce∥ blast crisis of cml mast cell leukemia acute eosinophilic leukemia, basophilic s leukemia acute lymphocyte leukemia (ALL) ①D 3 L1,L2,L3 T一ALL、B-ALL chronic leukemia:CML、P-LL、CLL、HCL、 2021/2/21 xie Yi, Hua Shan Hospital 8
2021/2/21 xie Yi,Hua Shan Hospital 8 According to the acute myeloid leukemia（AML） Differentiation & M0 M1 M2 ……………….. M7 Kind of cell blast crisis of CML，mast cell leukemia， acute eosinophilic leukemia，basophilic………… leukemia acute lymphocyte leukemia（ALL） L1，L2，L3 T－ALL、B－ALL chronic leukemia： CML、P－LL、CLL、HCL、 …… leukemia the tradition classification (FAB)of leukemia
WHO Classification(2001) 1, Acute myeloid leukemia(Aml) (1 AML with recurrent cytogenetic abnormalities AML with t(8: 21 (922/ 922),( AMLI/ETO) AML with t(15: 17)(922/ q12), (PML/RARa) AML with inv(16)(p13: 922)or t(1616(13:q22), CBFB/MY1 AML with 11g23(MLL) abnormallities 2021/2/21 xie Yi, Hua Shan Hospital 9
2021/2/21 xie Yi,Hua Shan Hospital 9 WHO classification (2001) 1, Acute myeloid leukemia(AML) (1), AML with recurrent cytogenetic abnormalities • AML with t(8;21)(q22;q22),(AML1/ETO) • AML with t(15;17)(q22;q12),(PML/RAR) • AML with inv(16)(p13;q22) or t(16;16)(p13;q22) ,CBF/MYH11 • AML with 11q23 (MLL) abnormalities
WHO classification(2001) (2), AML with mu/ti/ineage dysp/asia With prior mye/odysp/astic syndrome Without prior mye /odysp/astic syndrome 3), AML and mye/dysplastic syndrome therapy related Alkylating agent related Topoisomerase / inhibitor-related 2021/2/21 xie Yi, Hua Shan Hospital 10
2021/2/21 xie Yi,Hua Shan Hospital 10 WHO classification (2001) (2), AML with multilineage dysplasia • With prior myelodysplastic syndrome • Without prior myelodysplastic syndrome (3),AML and myelodysplastic syndrome, therapy related • Alkylating agent related • Topoisomerase ll inhibitor-related