Medical Genetics The Philadelphia Chromosome and Chronic Myelogenous Leukemia(CML) Normal Chromosomes Translocated Chromosomes Trans location fused abl gene abl-bcr bcr gene gene→ 22(Philadelphia elongated chromosome The translocated abl gene inserts into the bcr gene. The two genes fuse. The altered abl gene functions improperly, resulting in CML
Medical Genetics
Medical Genetics d53 dert 8日 9 22 9teg;22)22
Medical Genetics
Medical Genetics The connection between this chromosomal abnormality and CMl was clarified by studying the genes located on the chromosomes at the sites of the translocation breakpoints
Medical Genetics The connection between this chromosomal abnormality and CML was clarified by studying the genes located on the chromosomes at the sites of the translocation breakpoints
Medical Genetics In one of the translocated chromosomes, part of a gene called ab/ is moved from its normal location on chromosome g to a new location on chromosome 22. This breakage and reattachment leads to an altered abl gene. The protein produced from the mutant ab/ gene functions improperly, leading to CML
Medical Genetics In one of the translocated chromosomes, part of a gene called abl is moved from its normal location on chromosome 9 to a new location on chromosome 22. This breakage and reattachment leads to an altered abl gene. The protein produced from the mutant abl gene functions improperly, leading to CML
Medical Genetics 2. oncogene Oncogenes are mutated forms of genes that cause normal cells to grow out of control and become cancer cells. They are mutations of certain normal genes of the cell called proto-oncogenes
Medical Genetics 2. oncogene Oncogenes are mutated forms of genes that cause normal cells to grow out of control and become cancer cells. They are mutations of certain normal genes of the cell called proto-oncogenes