Medical Genetics Offspring have a 50% chance of receiving the mutant gene from a heterozygous parent, and 90%/ of carriers will develop retinoblastoma, usually in both eyes. The hereditary form is also associated with a high risk for other cancers especially of the bone and fibrous tissues (osteosarcomas and fibrosarcoma
Medical Genetics Offspring have a 50% chance of receiving the mutant gene from a heterozygous parent, and 90% of carriers will develop retinoblastoma, usually in both eyes. The hereditary form is also associated with a high risk for other cancers especially of the bone and fibrous tissues (osteosarcomas and fibrosarcoma
Medical Genetics Sporadic retinoblastoma is a trait in which the affected individual has not inherited any mutant alleles of the retinoblastoma gene
Medical Genetics Sporadic retinoblastoma is a trait in which the affected individual has not inherited any mutant alleles of the retinoblastoma gene
Medical Genetics The mutations occur after birth and result in tumor formation Tumors usually develop in only one eye and patients are not at high risk for other cancers both alleles need to be mutated in a single cell, and that is why this form typically occurs only in one eye
Medical Genetics The mutations occur after birth and result in tumor formation. Tumors usually develop in only one eye and patients are not at high risk for other cancers. Both alleles need to be mutated in a single cell, and that is why this form typically occurs only in one eye
Medical Genetics Hereditary Spora retinoblastoma relinoblastoma First Mutation RB I atation utation HB目RB Retinoblastoma Retinoblastoma a
Medical Genetics
Medical Genetics Chromosome and tumors Detailed studies of the philadelphia chromosome show that most of chromosome 22 has been translocated onto the long arm of chromosome 9. In addition the small distal portion of the short arm of chromosome 9 is translocated to chromosome 22. this translocation, which is found only in tumor cells indicates that a patient has chronic myelogenous leukemia(CML). In CML, the cells that produce blood cells for the body(the hematopoietic cells grow uncontrollably, leading to cancer
Medical Genetics Chromosome and tumors Detailed studies of the Philadelphia chromosome show that most of chromosome 22 has been translocated onto the long arm of chromosome 9. In addition, the small distal portion of the short arm of chromosome 9 is translocated to chromosome 22. This translocation, which is found only in tumor cells, indicates that a patient has chronic myelogenous leukemia (CML). In CML, the cells that produce blood cells for the body (the hematopoietic cells) grow uncontrollably, leading to cancer