Something we learn from textbook White fat cell -Store energy Monolocular(单房的)Q Brown fat cell Dissipate energy Thigh mitochondrial UCPl(uncoupling protein 1) Multilocular In small mammals, not in large mammals after infancy
Something we learn from textbook • White fat cell – Store energy – Monolocular(单房的) • Brown fat cell – Dissipate energy [high mitochondrial UCP1(uncoupling protein 1)] – Multilocular – In small mammals, not in large mammals after infancy
Some new progress ·“ brown conversion” of white fat cold or cAMP White fat tissue ·UCP1+ UCP1 brown fat cell UCP1+ Derived from myf-5 lineage Brown fat in adult humans UCP1+ Particularly in supraclavicular and neck region
Some new progress • “brown conversion”of white fat • Brown fat in adult humans – UCP1+ – Particularly in supraclavicular and neck region cold or cAMP White fat tissue • UCP1﹣ brown fat cell • UCP1+ • Derived from myf-5 lineage • UCP1+
Questions Beige fat cell is a distinct cell type or derived from white fat cells The brown fat tissue in adult human is classical brown fat or beige fat
Questions • Beige fat cell is a distinct cell type or derived from white fat cells ？ • The brown fat tissue in adult human is classical brown fat or beige fat ?
么}NR Public access Manuscript p HEAD Cell. Author manuscript: available in PMC 2013 July 20 Published in final edited form as Ce.2012July20:1502):366-376.doi:10.1016/12012.05.016 U> Beige Adipocytes are a distinct Type of Thermogenic Fat cell in Mouse and human c0o Jun Wu, Pontus Bostrom, Lauren M. Sparks LiYe, Jang Hyun Choi, An-Hoa Giang Melin Khandekar', Pirjo Nuutila5, Gert Schaart, Kexin Huang 6, Hua Tu6, Wouter D. van Marken Lichtenbelt. Joris Hoeks 2 Sven Enerback Patrick Schrauwen 2 and Bruce M spiegelman WAT: white adipose tissue BAT: brown adipose tissue Lecturer: Cao lijie
第一PPT模板网 Lecturer: Cao Lijie WAT: white adipose tissue BAT: brown adipose tissue
Beige adipocyte in white fat eige fat cell readily detectable in Inguinal subcutaneous fat depot ; Multilocular UCP1 between Wat and BAT Adipose tissues a Bat BAT 口|n E Inguinal subcutaneous fat depot 口Epi pididymal WaT [Ucp-T CIdea Pac-a t) Brown fat cell-enriched protein
Beige adipocyte in white fat • Multilocular • UCP1 between WAT and BAT BAT Inguinal subcutaneous fat depot Epididymal WAT Brown fat cell-enriched protein Beige fat cell readily detectable in Inguinal subcutaneous fat depot