慢性肉芽肿性疾病 (chronic guanulomatous diseasse) 一、X连锁/常染色体隐性遗传性疾病 二、 NADPH氧化酶缺乏 三、过氧化氢酶阳性菌感染

概念 Definition 具有血管系统的活体组织对损伤因子所发生的防御反应。(杨光华主编:第五版) Inflammation is the reaction of vascularized living tissues to local injury, leading to the accumulation of fluid and leukocytes in extravascular tissues. (Basic Pathology) 修复 repair: Defensive reaction

ANTITHROMBOTIC PROPERTIES Inhibition of platelet aggregation: PGL NO, ADPase Anticoagulant -binding and inhibition of thrombin: Antithrombin acceleration by heparin-like molecules, thrombomodulin activation of protein C/S, a2-macroglobulin. Fibrinlysis: Tissue plasminogen activator (tPA)

Etiology Thrombosis Embolism Vesospasm Expansion of atheroma Extrinsic compression Twisting of the vessels

Motional pathway of embolus: Embolus from left heart cavity or arterial system Embolus from right heart cavity or venous system Embolus from portal veins Paradoxical embolism Retrograde ethrombus

Arterial hyperemia Inflammatory Collateral Post-ischemic

CELLULAR ADAPTATION Excessive physiologic stresses. Some pathologic stimuli. A new, but altered state preserving the viability of the cell

Autopsy Biopsy Cytology Experimental studies In vitro: Tissue culture Organ culture Cell culture In vivo: Experimental animals Nude mice

Definition of pathology Pathology is to study diseases by scientific methods. Disease may be defined as an abnormal alteration of structure or function in any part of the body

Common type of necrosis after exogenous stimuli. Swelling, denaturation and coagulation of proteins Breakdown of cellular organelles Cell rupture